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Pattie
S Green PhD
Acting Instructor
Department of Medicine
Division of Gerontology and Geriatric Medicine
Seattle VAPSHCS GRECC MS151S
1660 S. Columbia Way
Bldg. 13, Room 114
Box 358280
Seattle WA 98108
Phone: (206)
277-5553
Fax: (206)764-2391
psgreen@u.washington.edu |
| 1990-1994 |
BS-Majors:
Microbiology, English; Minor: Chemistry, University of Florida |
| 1995-1999 |
PhD-Pharmacodynamics,
University of Florida |
| 1999-2000 |
Post-Doctoral
Associate
Center for Neurobiology of Aging, University of Florida,
Gainesville FL |
| 2001-2002 |
Research Associate
Washington University School of Medicine, St Louis MO |
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Peer
Reviewed Publications |
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Green,
P.S., K.E.
Gridley and J.W. Simpkins. (1996) Estradiol protects against b-amyloid
(25-35)-induced toxicity in SK-N-SH human neuroblastoma cells.
Neuroscience Letters
218: 165-168.
Green,
P.S., Bishop,
J. and Simpkins, J.W. (1997)
17a-Estradiol
exerts neuroprotective effects on SK-N-SH cells.
Journal of Neuroscience 17: 511-515.
Green,
P.S., Gordon,
K. and Simpkins, J.W. (1997)
Phenolic A ring requirement for the neuroprotective effects of
steroids. Journal of Steroid Biochemistry and Molecular Biology 63: 229-235.
Gridley,
K.E., Green, P.S. and
Simpkins, J.W. (1997) Low concentrations of estradiol reduce
b-amyloid
(25-35)-induced toxicity, lipid peroxidation and glucose
utilization in human SK-N-SH neuroblastoma cells. Brain
Research 778: 158-165.
Green,
P.S.,
Gridley, K.E. and Simpkins, J.W. (1998) Nuclear estrogen
receptor-independent neuroprotection by estratrienes: A novel
interaction with glutathione. Neuroscience 84: 7-10.
Gridley,
K.E., Green, P.S. and
Simpkins, J.W. (1998) A novel, synergistic interaction between
estradiol and glutathione protects neurons against
b-amyloid
25-35-induced toxicity in vitro. Molecular
Pharmacology 54: 874-880.
Zaulynov,
L., Green, P.S. and
Simpkins, J.W. (1999) Glutamate receptor requirement for neuronal
death from anoxia-reoxygenation: and in vitro model for assessment
of the neuroprotective effects of estrogens. Cellular
and Molecular Neurobiology 19: 705-718.
Persky,
A., Green, P.S.,
Zaulynov, L., Brazeau, G. and Simpkins, J.W. (2000) Protective
effect of estrogens against oxidative damage to heart and skeletal
muscle in vivo and in vitro. Proceedings
of the Society for Experimental Biology and Medicine 223:
59-66.
Green,
P.S.,
Perez, E.J., Calloway, T. and Simpkins, J.W. (2000) Estradiol
attenuation of b-amyloid-induced
toxicity: a comparison of MTT and calcein AM assays. Journal
of Neurocytology. 29: 419-423.
Green,
P.S., Yang,
S-H., Nilsson, K.R., Kumar, A.S., Covey, D.F. and Simpkins, J.W.
(2001) The non-feminizing enantiomer of 17b-estradiol
exerts protective effects in neuronal cultures and a rat model of
cerebral ischemia. Endocrinology
142: 400-406.
Wang,
J., Green, P.S., and
Simpkins, J.W. (2001) Estradiol protects against ATP depletion,
mitochondrial membrane potential decline and generation of
reactive oxygen species induced by 3-nitropropionic acid in SK-N-SH
human neuroblastoma cells. Journal
of Neurochemistry 77: 804-811.
Adams,
S.A., Green, P.S.,
Claxton, R., Simcox, R.S., Williams, M.V., Walsh K. and
Leeuwenburgh, C. (2001) Reactive carbonyl formation by oxidative
and non-oxidative pathways. Frontiers
in Bioscience 6:17-24.
Green,
P.S. and
Leeuwenbergh, C. (2002) Mitochondrial dysfunction is an
early indicator of doxorubicin-induced apoptosis.
Biochimica
et Biophysica Acta
1588:94-101.
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Invited
Editorials and Rreviews |
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Simpkins,
J.W., Green, P.S.,
Gridley, K.E., Singh, M., de Fiebre, N. and Rajakumar, G.
(1997) Role of
estrogen replacement therapy in memory enhancement and the
prevention of neuronal loss associated with Alzheimer's disease.
American Journal of
Medicine 103:195-255.
Simpkins,
J.W., Green, P.S.,
Gridley, K.E. and Shi, J. (1997) Estrogens and memory protection. Journal of Society Obstetricians and Gynaecologists of Canada
19:14s-19s.
Simpkins,
J.W., Rabbani, O., Shi, J., Panickar, K., Green,
P.S., and Day, A.L. (1998) A system for the brain-enhanced
delivery of estradiol: an
assessment of its potential for the treatment of Alzheimer’s
disease and stroke. Pharmazie
53: 505-511.
Green,
P.S. and
Simpkins, J.W. (2000) Neuroprotective effects of estrogens:
potential mechanisms of action.
International Journal of Developmental Neuroscience 18:
347-358.
Green,
P.S. and
Simpkins, J.W. (2000) Estrogens and estrogen-like non-feminizing
compounds: their role in the prevention and treatment of Alzheimer’s
disease. Annals of the New York Academy of Sciences 924: 93-98.
Green,
P.S.
and Bu, G. (2002) Phosphorylation of low-density lipoprotein
receptor-related protein (LRP) by PDGF. Current Opinions in
Lipidology 13:569-572.
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Other
Publications |
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Simpkins,
J.W., Green, P.S. and
Gridley, K.E. (1997) Fundamental role for estrogens in cognition
and neuroprotection.
In: Pharmacological Treatment of Alzheimer's Disease, Eds.
Brioni, J.D. and M.W. Decker. Wiley-Lisps, Inc., New York.
503-524.
Green,
P.S., Dawson, R. Jr., Wallace, D.R. and Owens, J. (1998)
Treatment of rat brain membranes with taurine increases
radioligand binding. In: Taurine 3: Cellular and Regulatory
Mechanisms, Eds. S. Schaffer, J.B. Lombardini and R.J. Huxtable.
Plenum Press, New York. 377-383.
Green,
P.S., Yang, S-H. and Simpkins, J.W. (2000) Neuroprotective
effects of phenolic A ring estrogens. In: Neuronal and Cognitive
Effects of Oestrogens. Wiley, Chichester (Novartis Foundation
Symposia). 230: 202-13.
Simpkins,
J.W., Green, P.S.,
Gridley, K.E., Shi, J. and Monck, E.M. (2000) Neuroprotective
effects of estrogens. In: International Symposium on Biology of
Menopause Serno Symposia USA.
103-111.
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