Division of Gerontology and Geriatric Medicine

Division of Gerontology and Geriatric Medicine

MAY J REED MD
Associate Professor
Division of Gerontology and Geriatric Medicine
Department of Medicine
University of Washington School of Medicine Seattle WA

Harborview Medical Center
325 9th Ave Box 359755
Seattle WA 98104-2499

Phone: (206) 341-5331
Fax: (206) 731-8753
E-Mail: mjr@u.washington.edu

Licensure and Certification

Licensure:	State of Washington
Board Certification:
1987	National Board of Medical Examiners
1989	American Board of Internal Medicine
1992	American Board of Internal Medicine Certificate of Added Qualification in Geriatric Medicine

Education

1982	BS University of Scranton, Biology, Summa Cum Laude
1986	MD Harvard University Medical School

Postgraduate Training

1990-92	Fellow University of Washington School of Medicine Department of Medicine Division of Gerontology and Geriatric Medicine
1989	Visiting Physician, Internal Medicine, Indian Health Service Hospital, Shiprock NM
1986-89	Internship and Residency, Primary Care/Internal Medicine, Massachusetts General Hospital, Boston MA

Faculty Positions

1992-1995	Acting Instructor/Senior Fellow University of Washington School of Medicine Department of Medicine Division of Gerontology and Geriatric Medicine
1995-2001	Assistant Professor University of Washington School of Medicine Department of Medicine Division of Gerontology and Geriatric Medicine
2001-present	Associate Professor University of Washington School of Medicine Department of Medicine Division of Gerontology and Geriatric Medicine

Honors

1986	Alpha Sigma Nu, National Jesuit Honor Society
1986	Aesulapian Club, Harvard University Medical School
1991-1993	Pfizer/American Geriatrics Society Postdoctoral Fellowship Award
1993	Merck/American Geriatrics Society New Investigator Award
1994-1995	AFAR Research Award
1995-1996	Sandoz Foundation Research Award
1996-2001	Paul Beeson Faculty Scholar in Aging Research Award
1998	University of Washington School of Medicine New Investigator Award

Bibliography

1	Pindyck J, Avorn J, Kuriyan M, Reed M J, Iqbal M, Levine S. Blood Donation by the Elderly: Clinical and Policy Considerations. J Am Med Assoc 257, 1186-1188, 1987.
2	Kuchel G, Avorn J, Reed M J, Fields D. Cardiovascular Responses to Phlebotomy and Sitting in Middle Aged and Elderly Subjects. Arch Int Med 152, 366-370, 1992.
3	Reed M J, Puolakkainen P, Lane T, Dickerson D, Bornstein P, Sage E H. Differential Expression of SPARC and Thrombospondin 1 in Wound Repair: Immunolocalization and in situ hybridization. J Histochem Cytochem 41, 1467-1477, 1993.
4	Reed M J, Vernon R, Abrass I, Sage E H. TGF-ß Induces the Expression of Type I Collagen and SPARC, and Enhances Contraction of Collagen Gels, by Fibroblasts from Young and Aged donors. J Cell Physiol 158:169-179, 1994.
5	Liska D J, Reed M J, Sage E H, Bornstein P. Cell-specific Expression of a1(I) collagen -hGH Minigenes in Transgenic Mice. J Cell Biol 125(3):695-704, 1994.
6	Puolakkainen P A , Twardzik D , Ranchalis J, Pankey S, Reed M J, Gombotz W. The Enhancement in Wound Healing by Transforming Growth Factor Beta1 Depends on the Topical Delivery System. J Surg Res 58:321-329, 1995.
7	Puolakkainen P A, Reed M J, Gombotz W R, Twardzik D R, Abrass I B, Sage E H. Acceleration of Wound Healing in Aged Rats by Topical Application of Transforming Growth Factor Beta 1. Wound Rep Reg 3(3):330-339, 1995.
8	Reed M J, Iruela-Arispe L, Truong T, O'Brien E, LaBell T, Bornstein P, and Sage E H. Thrombospondin Expression in Endothelial Cells: Correlation of TSP1 with Activated Endothelium. Am J Pathol 147:1068-1080, 1995.
9	Pichler R H, Bassuk JA, Hugo C, Reed M J, Eng E, Gordon KL, Pippin J, Alpers CE, Couser WG, Sage EH, Johnson RJ. SPARC is Expressed by Mesangial cells in Experimental Mesangial Proliferative Nephritis and Inhibits PDGF-mediated Mesangial Cell Proliferation in vitro. Am J Pathol 148:1153-1167, 1996.
10	Reed M J, Penn P E, Li Y, Birnbaum R, Vernon R B, Johnson T S, Pendergrass W R, Sage E H, Abrass I B, Wolf N S. Enhanced Cell Proliferation and Biosynthesis Mediate Improved Wound Repair in Refed, Caloric Restricted Mice. Mech Ageing Dev, 89:21-43, 1996.
11	Pichler R H, Bassuk JA, Hugo C, Reed M J, Gordon KL, Pippin J, Alpers CE, Couser WG, Sage EH, Johnson RJ. SPARC is Expressed in Renal Interstitial Fibrosis and in Renal Vascular Injury. Kidney International, 50:1978-1989, 1996.
12	Soderling J, Reed M J, Corsa A, Sage E H. Cloning and Expression of Mouse SC1, a Gene Product Homologous to SPARC. J Histochem Cytochem , 45(1):1-13, 1997.
13	Reed M J, Corsa A, Penn P, Pendergrass W, Sage E H, Abrass IB. Neovascularization of Sponge Implants in Aged Mice: Delayed Angiogenesis is Coincident with Decreased Levels of TGF-ß1 and Type I Collagen. Am J Path, 152(1):113-123, 1998.
14	Arthur W T, Vernon R B, Sage E H, Reed M J. Growth Factors Reverse the Impaired Sprouting of Microvessels from Aged Mice. Microvasc Res, 55:260-270, 1998.
15	Puolakkainen P, Reed M J, Vento P, Sage E H, Kiviluoto T, Kivilaakso E. Expression of SPARC in Healing Intestinal Anastomoses and in Short Bowel Syndrome in rats. Digestive Disease Sciences 44(8):1554-1564, 1999.
16	Bassuk J, Pichler R, Rothmeir J, Pippen J, Gordon K, Meek R, Bradshaw A, Lombardi D, Stranjord T, Reed M, Sage H, Couser W, Johnson R. Induction of TGF-ß1 by the Matricellular Protein SPARC in a Rat Model of Glomerular Nephritis. Kidney International, 57(1):117-128, 2000.
17	Reed M J, Corsa A, Kudravi S, McCormick R, Arthur WT. A Deficit in Collagenase Activity Contributes to Impaired Angiogenesis in Aging. J Cell Biochem, 77(1):116-126, 2000.
18	Reed MJ, Ferara N, Vernon RB. Impaired Migration, Integrin Function, and Actin Cytoskeletal Organization in Dermal Fibroblasts from a Subset of Aged Human Donors. Mech Ageing Dev, 122:1203-1220, 2001.
19	Bradshaw AD, Reed MJ, Carbon JG, Pinney E, Brekken RA, Sage EH. Increased Fibrovascular Invasion of Subcutaneous Polyvinyl Alcohol Sponges in SPARC-Null Mice. Wound Rep Regen, 6:522-530, 2001.
20	Bradshaw AD, Reed MJ, Sage EH. SPARC Null Mice Exhibit Accelerated Cutaneous Wound Closure. J Histochem Cytochem, 50 (1): 1-10, 2002.
21	Koike T, Vernon RB, Hamner M, Sadoun E, Reed MJ. MT1-MMP, but not Secreted Collagenases, Influences the Migration of Human Microvascular Endothelial Cells in 3-Dimensional Collagen. J Cell Biochem 86:748-758, 2002.
22	Reed, MJ, Koike T, Sadoun E, Sage EH, Puolakkainen P. Inhibition of TIMP1 Enhances Angiogenesis in vivo and Cell Migration in vitro. Microvasc Res Jan;65 (1):9-17, 2003.
23	Puolakkainen P, Bradshaw A, Kyriakides T, Reed MJ, Brekken R, Bornstein P, Sage EH. Compromised production of extracellular matrix in mice lacking SPARC leads to a reduced foreign body reaction to implanted biomaterials. Am J Pathol 162(2):627-35, 2003.

Book Chapters, Reviews

1	SPARC and the Extracellular Matrix: Implications for Cancer and Wound Repair. May J. Reed and E. Helene Sage in Current Topics in Microbiology and Immunology, U Gunthert and W Birchmeier, Editors; Springer-Verlag, Berlin, 1996.
2	Kudravi S and Reed MJ. Aging, Cancer, and Wound Healing. In Vivo, 14(1):83-92, 2000.
3	Wound Repair in Aging. May J. Reed, Pauli Puolakkainen, Teruhiko Koike in Wound Healing: Methods and Protocols, AL Burns-Harring and LA DiPietro, Editors; Humana Press, 2003.

Other Publications

1	Reed M, Hibberd P. Endoscopy and Endophthalmitis. N Engl J Med 321, 836c, l989.
2	Reed M J and Weksler M E. Wound repair in older patients: preventing problems, managing healing. Geriatrics, 53(5) 88-94, 1998.
3	Reed M J. Health Promotions for Older Adults: Preventive Health Care. A publication of the Northwest Geriatric Education Center, Spring, 1999.

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Comments to David W Redick redick@u.washington.edu
January 15, 1998 - Last updated: August 26, 2003