Question | Discussion | References

Updated August 19, 2011

Indications for Initiating Antiretroviral Therapy in Resource-Limited Settings

Author: Christopher Behrens, MD

A 33-year-old Ethiopian woman with a history of papular pruritic eruptions and seborrheic dermatitis is diagnosed with HIV infection at her primary health clinic. Additional laboratory studies reveal normal blood counts and renal panel. Her CD4 count is 310 cells/mm3 (18%). She has no other illnesses and is not pregnant. She is interested in initiating antiretroviral therapy and has no apparent barriers to adherence.

According to the 2010 WHO Guidelines on Antiretroviral Therapy in Resource-Limited Settings, which of the following statements is TRUE regarding the initiation of antiretroviral therapy for this patient?

A Antiretroviral therapy is indicated because she has WHO Clinical Stage 3 disease.
B Antiretroviral therapy is indicated because her CD4 count is less than 350 cells/mm3.
C Antiretroviral therapy is not indicated at this time unless she progresses to WHO Stage 4 disease.
D Further laboratory testing is required in order to determine whether or not she should be started on antiretroviral therapy.