James Bennett, M.D., Ph.D.
Arnold Lee Smith Endowed Professorship for Research Faculty Development
Seattle Children's & UW Medicine
James (Jimmy) Bennett was born in New Orleans, LA. He received his M.D. and Ph.D. degrees from New York University School of Medicine where he studied mechanisms of early embryonic development in the laboratory of Alexander F. Schier, Ph.D, using zebrafish as a developmental model.
He moved to Seattle for his clinical residency and fellowship training at the University of Washington/ Seattle Children’s Hospital, and is triple boarded in Pediatrics, Clinical Genetics and Genomic, and Clinical Molecular Genetics.
His research is focused on the genetics of congenital malformations and developmental disorders in children. Almost all genetic testing in children is performed on DNA derived from blood, and assumes that each individual is born with a single genome. In fact, because DNA mutates with every cell division, individuals are born with more than one genome. Some of these mutations, which are called “post-zygotic” since they arise after the single cell zygote stage, are not easily detected in the blood. Dr. Bennett’s lab is interested in these types of mutations and believes they are an underappreciated cause of congenital malformations. He is using cutting-edge next generation DNA sequencing methods to identify these types of mutations and determine their significance in human development.
In addition to his research on post-zygotic mutations, Dr. Bennett also spends time seeing patients in pediatric genetics clinic, and has a particular interest in children with vascular malformations. He is also co-director of the Seattle Children’s Hospital Molecular Diagnostic lab, where he is focused on diagnosis using next generation sequencing and other DNA sequencing methods.
Dr. Bennett works to turn genetic research into specialized patient care. A recent example of the impact of his work can be found in the story of a family struggling to find a diagnosis for their young daughter.
Learn more about:
- James Bennett, M.D., Ph.D.
- Department of Pediatrics
- Division of Genetic Medicine
- The Center for Developmental Biology and Regenerative Medicine
- Seattle Children’s Hospital Genetics Laboratories
If you’re interested in this field, please consider making a gift to this fund through the UW Foundation.