Jeffrey A. Ledbetter, Ph.D.
Herndon and Esther Maury Endowed Professor in Rheumatoid Arthritis
Research Professor of Medicine, Division of Rheumatology
Affiliate Associate Professor, Department of Microbiology
Dr. Ledbetter, a rheumagologist, received a Ph.D.in cancer research from the University of Wisconsin and did fellowship training in immunology at Stanford.
Dr. Ledbetter was amongst the first to assess the effects of T cell depletion with monoclonal antibodies in immunologic diseases in animal models. He discovered CTLA4-Ig while working at Bristol-Meyers Squibb in 1991, and the drug (Orencia) was approved by the FDA for therapy of rheumatoid arthritis in 2008. Dr. Ledbetter also was an inventor of chimeric anti-CD20 mAbs for therapy of B cell lymphoma and for second-line therapy of rheumatoid arthritis. He is working on new therapies for autoimmune diseases.
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