Dr. McMillan's research interests include examining the role of insulin
and insulin signaling pathways in the etiology of Alzheimer's disease.
In collaboration with Dr. Craft, previous studies have demonstrated
Alzheimer's-associated alterations in the expression of insulin
degrading enzyme (IDE), an enzyme that degrades both insulin and beta
amyloid.  These alterations may impair beta amyloid clearance, leading
to its deposition into plaques.  Aberrant IDE expression may also result
in altered insulin levels and abnormal insulin signaling, which may play
a role in the development of Alzheimer's disease.  Current studies are
underway to determine if defective insulin function is related to
excessive glucocorticoid levels and oxidative stress