3^rd Genome Training Grant Trainee Symposium

Evolution of the Mitochondrial Genome

University of Washington, Seattle
Tuesday, June 12, 2007
Foege Auditorium

Speakers:

• Michael Gray, Dalhousie University
  
  Genomics vs. Proteomics: Different Views of Mitochondrial Evolution
• Jeffrey Palmer, Indiana University
  
  Horizontal Gene Transfer Gone Wild in Plant Mitochondrial Genomes
• David Rand, Brown University
  
  Mito-Nuclear Coevolution, Epistasis and Fitness
• Douglas Wallace, University of California, Irvine
  
  Mitochondria and Evolutionary Medicine, or: Why Do We Still Have a Maternally Inherited Mitochondrial DNA?

Event schedule:

Talks will be held in the Foege Auditorium, S-060.

Representative publications:

• Michael Gray

  search PubMed
  • The origin and early evolution of mitochondria. Michael W Gray, Gertraud Burger, and B. Franz Lang. Genome Biology, June 2001.
  • Mitochondrial genomes: anything goes. Gertraud Burger, Michael W. Gray, and B. Franz Lang. Trends in Genetics, 19:12, December 2003.
  • Bacteriophage origins of mitochondrial replication and transcription proteins. Timothy E. Shutt and Michael W. Gray. Trends in Genetics, 22:2, February 2006.

• Jeffrey Palmer

  search PubMed
  • Massive horizontal transfer of mitochondrial genes from diverse land plant donors to the basal angiosperm Amborella. Ulfar Bergthorsson, Aaron O. Richardson, Gregory J. Young, Leslie R. Goertzen and Jeffrey D. Palmer. PNAS: 101:51, p. 17747-52, December 2004.
  • Mitochondrial substitution rates are extraordinarily elevated and variable in a genus of flowering plants. Yangrae Cho, Jeffrey P. Mower, Yin-Long Qiu, and Jeffrey D. Palmer. PNAS, 101:51, p. 17741-17746, December 2004.
  • Evolution of mitochondrial gene content: gene loss and transfer to the nucleus. Keith L. Adams and Jeffrey D. Palmer. Molecular Phylogenetics and Evolution, 29:3, p. 380-395, December 2003.

• David Rand

  search PubMed
  • Nuclear-mitochondrial epistasis and drosophila aging: introgression of Drosophila simulans mtDNA modifies longevity in D. melanogaster nuclear backgrounds. David M. Rand, Adam Fry and Lea Sheldahl. Genetics, 172, p. 329-341, January 2006.
  • Cytonuclear coevolution: the genomics of cooperation. David M. Rand, Robert A. Haney and Adam J. Fry. Trends in Ecology & Evolution, 19:12, p. 645-653, December 2004.
  • Mitochondrial Genetics of Aging: Intergenomic Conflict Resolution. David M. Rand. Sci. Aging Knowl. Environ. November 2005.

• Douglas Wallace

  search PubMed
  • Why do we still have a maternally inherited mitochondrial DNA? Insights from evolutionary medicine. Douglas C. Wallace. Ann Rev Biochem, 76:31.1-31.41, June 2007.
  • Life extension through neurofibromin mitochondrial regulation and antioxidant therapy of Neurofibromatosis-1 in Drosophila. James Jiayuan Tong, Samuel E. Schriner, David McCleary, Brian J. Day, and Douglas C. Wallace. Nature Genetics (in press), March 2007.
  • A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine. Douglas C. Wallace. Annu Rev Genet, 39:359-407, 2005.

Acknowledgements

The symposium is made possible by support from the NIH/NHGRI. The title image for this page is an electron micrograph of mammalian mitochondria and comes from the LTSN Centre for Bioscience.

A feedback form is available to contact the webmaster or symposium organizers.