Fall Quarter 2017 dates coming soon
The HIV Neuropathogenesis Journal Club provides a forum for discussion of seminal papers and cutting-edge research in mechanisms of neuropathogenesis in adult and pediatric HIV, biomarkers for neuro-impairment, and strategies for intervention. The journal club meets bimonthly and is lead by:
– Christina M. Marra, MD, Professor, Neurology, Vice Chair (Academic Affairs), Neurology, Adjunct Professor, Medicine (Infectious Diseases), UW
– Claudia Crowell, MD, Assistant Professor, Pediatrics, UW
– Sarah Benki-Nugent, MS, PhD, Acting Assistant Professor, Global Health, UW
Our next Journal Club will be TBD.
November 30, 2016
A lipid storage-like disorder contributes to cognitive decline in HIV-infected subjects. – Veera Venkata Ratnam Bandaru, PhD, Michelle M. Mielke PhD, Ned Sacktor, MD, Justin C. McArthur MBBS, Igor Grant MD, Scott Letendre MD, Linda Chang MD, Valerie Wojna MD, Carlos Pardo MD, Peter Calabresi MD, Sody Munsaka PhD, Norman J. Haughley PhD. Neurology. 2013 Oct 22;81(17):1492-9. doi: 10.1212/WNL.0b013e3182a9565e. Epub 2013 Sep 11
Cerebrospinal fluid metabolomics implicate bioenergetic adaptation as a neural mechanism regulating shifts in cognitive states of HIV-infected patients – Alex M. Dickens, Daniel C. Anthony, Reena Deutsch, Michelle M. Mielke, Timothy D.W. Claridge, Igor Grant, Donald Franklin, Debra Rosario, Thomas Marcotte, Scott Letendre, Justin C. McArthur and Norman J. Haughey. AIDS. 2015 Mar 13;29(5):559-69. doi: 10.1097/QAD.0000000000000580.
A Biological Perspective of CSF Lipids as Surrogate Markers for Cognitive Status in HIV – Norman J. Haughey, Zhu Xiaomao, and Veera Venkata Ratnam Bandaru. J Neuroimmune Pharmacol. 2013 Dec;8(5):1136-46. doi: 10.1007/s11481-013-9506-0. Epub 2013 Nov 8.
September 21, 2016
Tiraboschi JM, Muñoz-Moreno JA, Puertas MC, Alonso-Villaverde C, Prats A, Ferrer E, Rozas N, Maso M, Ouchi D, Martinez-Picado J, Podzamczer D.Viral and inflammatory markers in cerebrospinal fluid of patients with HIV-1-associated neurocognitive impairment during antiretroviral treatment switch. HIV Med. 2015 Jul;16(6):388-92. doi: 10.1111/hiv.12243. Epub 2015 Feb 27.
Ndhlovu LC1, Umaki T, Chew GM, Chow DC, Agsalda M, Kallianpur KJ, Paul R, Zhang G, Ho E, Hanks N, Nakamoto B, Shiramizu BT, Shikuma CM.Treatment intensification with maraviroc (CCR5 antagonist) leads to declines in CD16-expressing monocytes in cART-suppressed chronic HIV-infected subjects and is associated with improvements in neurocognitive test performance: implications for HIV-associated neurocognitive disease (HAND). J Neurovirol. 2014 Dec;20(6):571-82. doi: 10.1007/s13365-014-0279-x. Epub 2014 Sep 17.
Melica G, Canestri A, Peytavin G, et al. Maraviroc-containing regimen suppresses HIV replication in the cerebrospinal fluid of patients with neurological symptoms. AIDS. 2010 Aug 24;24(13):2130-3.
Details to come
The Impact of HIV on Neurodevelopment in Kenya (INK) is an observational cohort study of child neurocognitive impairment in HIV-1-infected children with HIV-uninfected children as a comparison group. This study will involve 2 years of follow-up with annual neurocognitive assessments, and will be based in Nairobi Kenya. The INK Study will estimate the impact of ART on neurocognitive deficits in HIV-infected early-(infancy) and late-treated school-aged children. Separately, we will determine the relative impact of pre-ART HIV disease, response to ART, ART regimen, and immune activation on type and severity of neurocognitive deficits.
“Impact of HIV, immune activation, and ART on child neurodevelopment in Kenya”
Time Period: 08/01/2012 – 07/31/2017
PI: Sarah Benki-Nugent
Pediatric HIV infection is associated with an increased risk of neurodevelopmental deficits. The Mediational Intervention for Sensitizing Caregivers (MISC), an early childhood intervention aimed at improving caregiver-child interactions by facilitating caregiver directed mediated learning, has been shown to improve neurodevelopment. The MISC has been studied extensively as an individual-based intervention administered in the home; however, home-based interventions are time intensive, expensive and difficult to implement on a large-scale. In contrast, group-based interventions are less time-intensive, less costly and provide an extended support network. We hypothesize that implementation of the group-based MISC will be associated with improved neurodevelopment comparable to the individual-based MISC in HIV-infected children ages 1-3 years. We also hypothesize that the group-based MISC will be associated with better caregiver attitudes, improved caregiver mental health and better child HIV-related health outcomes similar to the individual-based MISC. We plan to test these conducting a three-arm pilot randomized control trial of the individual-based MISC versus the group-based MISC versus controls in Nairobi,Kenya. We anticipate that both intervention arms will have improved outcomes compared to the controls. We anticipate the group MISC is a feasible approach that can be evaluated in larger future studies and potentially scaled for programmatic implementation.
Clinical Research Scholar’s Program Seattle Children’s Hospital
Title: Improving Neurodevelopmental Outcomes of HIV-Infected Children in Kenya
PI: Claudia Crowell
Time Period: 7/1/2014 – 6/30/2016
Center for Clinical and Translational Research Pediatric Pilot Award
Title: A Pilot Study of the Effect of the Mediational Intervention of Sensitizing Caregivers (MISC) on Neurodevelopment in HIV-infected Children in Kenya
PI: Claudia Crowell
Time Period: 10/1/2013 – 9/30/2014
INK Neurocognitive Assessment Training
In April 2013, the INK study team carried out a training in Nairobi, Kenya. In January 2014, the INK study team went through further training on validated neurocogntitive tests facilitated by Michael Boivin, PhD, MPH and Global Health Uganda. The training focused on the Bruininks-Oseretsky Test of Motor Proficiency (BOT) and the Kaufman Assessment Battery for Children (KABC), which measures cognitive ability.
In 2013, Dr. Claudia Crowell, MD facilitated a skype training on the adapted Malawi Developmental Assessment Tool (MDAT) for the Nairobi and Kisumu study teams.
Mediational Intervention for Sensitizing Caregivers (MISC) Training: In January 2013, the MISCK study team traveled to Tororo, Uganda to attend a MISC training facilitated Deborah Givon and Cilly Shohet of the late Pnina Klein’s group at the Bar Ilan University, Israel.
The Regional Inter-agency Task Team on Children and AIDS in Eastern and Southern Africa is a network of organisations working together to influence global, regional and national policy formulation and implementation for children and their families. Through advocacy and knowledge management, we work on the three priority areas below to improve the care and support for children.
A global inter-agency consortium with strong links to regional networks and a track record of advocacy and knowledge generation and dissemination at an international level. Established in 1984 by a small group of donor funding agencies, it has evolved into a well-respected global network with committed partner agencies, institutions and professionals involved in the field of ECCD at all levels. The focus on young children (0 to 8yrs), their families and communities remains highly relevant in 2013 when taking into account the very large numbers of young children living in difficult and resource-poor contexts and the effects this has on their overall physical, social and cognitive development and well-being.
The Coalition brings funders and technical experts together to advocate for the best policy, research, and programs for children because children are a vulnerable population that has too often been overlooked.