Global WACh Research

As the global health community has re-prioritized the health of women, adolescents, and children (WACh), it is important for academic Centers to contribute unique advances in this field. To that aim, we are committed to fostering collaborative and multidisciplinary research focused on issues affecting WACh health around the world. Below are highlighted examples of Global WACh research and scientific discovery.

Impact of Indoor Air Pollution on the Health of HIV-1 Infected Children in KenyaDiscern the relationship of household air pollution to respiratory infections, growth, immune, and cognitive outcomes on HIV-1 infected children receiving ART and healthy childrenNIHChild Health
Pediatric HIV-1 in Africa: Pathogenesis and ManagementProvide mentorship to clinical research trainees in a new program focused on pediatric HIV-1 pathogenesis and management.NIHMaternal-Child Health
Mechanisms and Cofactors of HIV Transmission to WomenExamine the mechanisms by which biological cofactors increase susceptibility of women to HIV-1.NIHWomen’s Health
MEPI: Linked-Strengthening Maternal, Newborn and Child Health Research Training in KenyaEstablish a Collaborative Center of Excellence in Maternal, Newborn, & Child Health (MNCH) at the University of Nairobi (UON).NIHMaternal-Child Health
Coptic Hospital/ University of Washington Collaborative HIV-1 CareSupport the Coptic Orthodox Mission in the planning, implementation and development of the HIV clinics in Kenya.Coptic Hospital/CDCMaternal-Child Health
Urgent Versus Post-Stabilization ART in HIV-1 Infected Children with Severe Co-infectionCompare incidence mortality, IRIS and drug toxicity between arms and will determine co-factors for these outcomes.NIH/NICHDChild Healh
Prevention of Mother to Child Transmission- Mother and Child Health EvaluationDetermine the prevalence and co-factors of HIV testing, delivery and location and feeding groups in mother-infant pairs at 6 week MCH visits and in subgroupsCoptic Hospital/ CDCMaternal-Child Health
HIV-1 and Protective Immunity against Common Childhood PathogensProvide mentorship to clinical research trainees focused on HIV-1 and common childhood pathogens.NIHChild Health
HIV Testing and Educating Male Partners to Improve Maternal and Infant Outcomes (HOPE).Provide education and HIV testing to men in stable relationships with pregnant HIV infected and HIV-uninfected women in order to improve overall health of women and infants, reduce risk for vertical transmission and horizontal transmission, and increase identification of men living with HIV and link them to care.NIH/NICHDMaternal-Child Health
Women’s Lifecourse Events & HIV Transmission Potential: A Multidisciplinary StudyThis multidisciplinary study of HIV-positive Kenyan women will employ a rapidly evolving paradigm for understanding HIV transmission potential by employing simultaneous measurement of sexual risk behavior and adherence to antiretroviral therapy.NIH/NICHDMaternal-Child Health
ERIN CRC: Molecular Basis of Nontyphoidal Salmonella EmergenceWe propose to more clearly define the epidemiology of NTS disease in Africa by examining differences in host susceptibility, changes in strain diversity and virulence, and the role of asymptomatic carriage in promoting human-human transmission of NTS.NIH/NIAIDMaternal-Child Health
Prevalence and Correlates of Tuberculosis Identified in Non-Pulmonary Specimens Among Kenyan Children with Either Suspected Tuberculosis or Suspected Bloodstream InfectionA pilot study of TB prevalence in individuals with respiratory symptoms and predictors of pulmonary TB in Kenya.FirlandChild Health
Control of Oncogenic Viruses During Infancy: The Role of Concurrent Primary HIV-1 Infection and HAARTThe aims of this study are to determine the incidence of infection during the first 2 years of life, to determine whether concurrent primary infant HIV infection modifies the control of primary replication, and to compare the kinetics of replication between HIV-uninfected infants, antiretroviral-naive HIV-infected infants, infants treated with antiretroviral therapy in a cohort of children born to Kenyan HIV-1 infected women.NCI/FHCRC/CFARChild Health
Vertical CMV transmission in the setting of maternal HIV-1 infection in KenyaThe research will utilize specimen repositories from three randomized clinical trials to study interactions between HIV-1 and CMV during infancyNIAIDMaternal-Child Health
ARRA Latent TB Detection and Implications in HIV-1 Infected Women and Their ChildrenExpanding assessment of the sensitivity, specificity, predictive value, and correlates of mycobacterium tuberculosis (MTB)-specific interferon-gamma release assays (IGRAs) for detection of latent TB infection (LTBI) in HIV-1 infected women and their children.Maternal-Child Health
CDC-KenyaThe UW is providing a national PMTCT evaluation of large MCH programs in Kenya.Maternal-Child Health
Learning Grant Evaluating the Readiness of the Educational Systems in Rwanda, Kenya, and EthiopiaThis “learning grant” is yielding an action plan for educational scale up in three separate countries (Rwanda, Ethiopia and Kenya) that can be integrated into broader HRH funding efforts in the future.Child Health
The Role of Antibodies in Mother to Child HIV TransmissionThis proposal will test the hypothesis that broad and potent neutralizing antibody responses can help protect against HIV-1 infection, providing unique insights into the specificity of antibodies that are capable of blocking HIV-1 acquisition.Maternal-Child Health
Pediatric HIV-1 in Africa: Pathogenesis and ManagementProvide mentorship to clinical research trainees in a new program focused on pediatric HIV-1 pathogenesis and management.NIHChild Health