CURRENT CLINICAL INTERESTS
Disorders of hemostasis and thrombosis
CURRENT RESEARCH INTERESTS
Clinical and translational research in hemostasis, thrombosis, transfusion medicine, and sickle cell disease
Dr. Konkle has several active federally-funded studies focusing on the clinical impact of thrombosis. These include 1) A feasibility study of low molecular weight heparin to prevent postpartum thrombosis in women at higher risk for venous thromboembolism (NHLBI R34), 2) A study to determine biomarkers predictive of heparin-induced thrombocytopenia in patients undergoing cardiac catheterization and cardiopulmonary bypass surgery (NIH RC1), 3) A cross sectional analysis of cardiovascular disease and complications of anticoagulant and antithrombotic therapy in men with moderate and severe hemophilia (CDC), and 4) A study of N-acetylcysteine in patients with sickle cell disease to evaluate safety and laboratory endpoints of hemolysis and changes in von Willebrand factor (NHLBI RO1).
She has a long standing interest in laboratory assessment of bleeding and thrombotic disorders and in the development of new testing. She is co-leading a nationwide project to provide mutation analysis to patients with hemophilia, to assess next generation sequencing in this context, and to provide a repository for future research. She is evaluating laboratory assays for von Willebrand disease and hemophilia with aims to develop testing with improved correlation with bleeding phenotype, and to predict thrombotic risk postpartum.
She is involved in clinical trials of new therapies for hemophilia and von Willebrand disease, and studies of outcomes in hemophilia (HUGS).
Bauer TL, Arepally G, Konkle BA,
Mestichelli B, Shapiro SS, Cines DB, Poncz M, McNulty S, Amiral J,
Hauck WW, Edie RN, Manion JD: Prevalence of heparin-associated
antibodies without thrombosis in patients undergoing cardiopulmonary
bypass surgery. Circulation 95:1242-1246, 1997.
Konkle BA, Bauer KA, Weinstein R,
Greist A, Holmes HE, Bonfiglio J: Use of recombinant antithrombin (AT)
in patients with congenital AT deficiency undergoing surgical
procedures. Transfusion. 43:390-394, 2003.
Melendez-Morales L, Konkle BA,
Preiss L, Zhang M, Mathew P, Eyster ME, Goedert JJ. Chronic hepatitis
B and other correlates of spontaneous clearance of hepatitis C virus
among HIV-infected people with hemophilia. AIDS. 21:1631-1636,
Konkle BA, Ebbesen LS, Erhardtsen
E, Bianco RP, Lissitchkov T, Rusen L, Serban MA. Randomized,
prospective clinical trial of rFVIIa for secondary prophylaxis in
hemophilia patients with inhibitors. J Thromb Haemost.
Blomback M, Konkle BA, Manco-Johnson MJ, Bremme K, Hellgren M, Kaaja R. ISTH SSC Subcommittee on Women’s Health Issues. Preanalytical conditions that affect coagulation testing, including hormonal status and therapy. J Thromb Haemost. 2007;5:855-858. PMCID: PMC1890816.
Shihong I, Morris D, Konkle BA.
Platelet von Willebrand factor determination does not improve the
diagnosis of patients with suspected Type 1 von Willebrand disease. Haemophilia.
Konkle BA, Kessler C, Aledort L,
Andersen J, Fogarty P, Kouides P, Quon D, Ragni M, Zakarija A,
Ewenstein B. Emerging clinical concerns in the ageing haemophilia
patient. Haemophilia 15:1197-1209, 2009.
Metjian A, Wang C, Sood S, Cuker A, Peterson S, Soucie J, Konkle BA. Bleeding symptoms and laboratory correlation in patients with severe von Willebrand disease. Haemophilia. 15:918-925, 2009.
Cuker A, Arepally G, Crowther MA, Rice L, Datko
F, Hook K, Propert KJ, Kuter DJ, Ortel TL, Konkle
BA, Cines DB. The HIT expert probability (HEP) score: a novel pre-test probability model for heparin-induced thrombocytopenia based on broad expert opinion. J Thromb Haemost. 8:2642-2650, 2010.
Soucie JM, Wang C, Siddiqi A, Kulkarni R, Recht M, Konkle BA and The Hemophilia Treatment Center Network. The longitudinal effect of body adiposity on joint mobility in young males with Haemophilia A. Haemophilia. 17:196-203, 2011.
Sood SL, Cuker A, Wang C, Metjian AD, Chiang EY, Soucie JM, Konkle BA and the HTCN Study Investigators. Similarity in joint function limitation in type 3 von Willebrand disease and moderate Hemophilia A. Haemophilia (accepted for publication), 2012.