Education and Training:

B.S., Honors, Chemistry, University of Washington (1970)

M.S., Biology (Molecular Biology, Neurophysiology) California Institute of Technology, Pasadena, CA (1973)

M.D., University of Washington School of Medicine, Seattle, WA (1977)

Externship, The National Hospital, Institute of Neurology, Queen Square, London, UK (1977)

Internship, Internal Medicine (Categorical), St. Louis University Affiliated Hospital, St. Louis, MO (1977-78)

Residency, Internal Medicine (Categorical), University of Oregon Health Sciences Center, Portland, OR (1978-80)

Senior House Officer and Registrar (Locum), Neurology, The National Hospital Institute of Neurology, Queen Square, London, UK (1979)

Fellowship, Clinical Hematology/Medical Oncology, University of Oregon Health Sciences University, Portland, OR (1980-82)

Fellowship, Senior Research Associate, Department of Basic and Clinical Research, Scripps Clinic and Research Foundation, La Jolla, CA (1982-83)

CURRENT CLINICAL INTERESTS

Disorders of hemostasis and thrombosis
Disorders of the central nervous system
Adult hematology

CURRENT RESEARCH INTERESTS

Clinical studies of acute intervention in ischemic stroke
Hemostasis problems associated with cerebral injury
Vascular and matrix adhesion biology of the CNS

RESEARCH DESCRIPTION

The work in our laboratory is focused on the hemostasis, ultrastructure, and normal signaling within the cerebral microvasculature, and their responses to conditions of injury, including ischemia.  These studies follow from the consequences of focal ischemia in stroke patients.  Current work examines the interactions of the cellular and matrix components of the neurovascular unit (including the endothelium, astrocytes, and cells of the monocytoid lineage), and their relationships to the integrity of the blood brain barrier. This group has had a long-term interest in clinical recanalization methods in thrombotic-thromboembolic stroke and their consequences to hemostasis, to the neurovascular unit, and to the evolution of brain injury and recovery.

SELECTED PUBLICATIONS

del Zoppo GJ. Perspective: stroke and neurovascular protection.  N. Engl. J. Med. 354:553-555, 2006

del Zoppo GJ, Milner R, Mabuchi T, Hung S, Wang X, Berg GI, Koziol JA.  Microglial activation and matrix protease generation during focal cerebral ischemia.  Stroke 38:646-651. 2007

Adams HP, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A, Grubb RL, Higahsida RT, Jauch EC, Kidwell C, Lyden PD, Morgenstern LB, Quershi AI, Rosenwasser RH, Scott PA, Wijdicks EFM.  Guidelines for the early management of adults with ischemic stroke.  Stroke 38:1635-1711, 2007.

Milner R, Hung S, Wang X, Berg GI, Spatz M, del Zoppo GJ.  Responses of endothelial cell and astrocyte matrix integrin receptors to ischemia mimic those observed in the neurovascular unit.  Stroke 39:191-197, 2008

Milner R, Hung S, Wang X, Spatz M, del Zoppo GJ.  The rapid decrease in astrocyte-associated dystroglycan expression by focal cerebral ischemia is protease dependent.  J. Cereb. Blood Flow Metab. 28:812-823, 2008