Education and Training:
B.S., Honors, Chemistry, University of Washington (1970)
M.S., Biology (Molecular Biology, Neurophysiology) California Institute of Technology, Pasadena, CA (1973)
M.D., University of Washington School of Medicine, Seattle, WA (1977)
Externship, The National Hospital, Institute of Neurology, Queen Square, London, UK (1977)
Internship, Internal Medicine (Categorical), St. Louis University Affiliated Hospital, St. Louis, MO (1977-78)
Residency, Internal Medicine (Categorical), University of Oregon Health Sciences Center, Portland, OR (1978-80)
Senior House Officer and Registrar (Locum), Neurology, The National Hospital
Institute of Neurology, Queen Square, London, UK (1979)
Fellowship, Clinical Hematology/Medical Oncology, University of Oregon Health Sciences University, Portland, OR (1980-82)
Fellowship, Senior Research Associate, Department of Basic and Clinical Research, Scripps Clinic and Research Foundation, La Jolla, CA (1982-83)
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Gregory J. del Zoppo, M.D.
Professor of Medicine, Division of Hematology
Adjunct Professor of Neurology
University of Washington School of Medicine
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Office Address:
Harborview Medical Center
Research & Training Bldg., Room 503b
325 Ninth Ave.
Seattle, WA 98104
Phone: (206) 897-5313
Fax: (206) 343-5043
E-mail:
grgdlzop@u.washington.edu |
CURRENT CLINICAL INTERESTS
Disorders of hemostasis and thrombosis
Disorders of the central nervous system
Adult hematology
CURRENT RESEARCH
INTERESTS
Clinical studies of acute intervention in ischemic stroke
Hemostasis problems associated with cerebral injury
Vascular and matrix adhesion biology of the CNS
RESEARCH DESCRIPTION
The work in our laboratory is
focused on the hemostasis, ultrastructure, and normal signaling within the cerebral microvasculature, and their responses to
conditions of injury, including ischemia. These studies follow
from the consequences of focal ischemia in stroke patients.
Current work examines the interactions of the cellular and matrix
components of the neurovascular unit (including the endothelium,
astrocytes, and cells of the monocytoid lineage), and their
relationships to the integrity of the blood brain barrier. This group
has had a long-term interest in clinical recanalization methods in
thrombotic-thromboembolic stroke and their consequences to hemostasis,
to the neurovascular unit, and to the evolution of brain injury and
recovery.
SELECTED
PUBLICATIONS
del Zoppo GJ.
Perspective: stroke and neurovascular protection. N. Engl. J.
Med. 354:553-555, 2006
del Zoppo GJ, Milner R,
Mabuchi T, Hung S, Wang X, Berg GI, Koziol JA. Microglial
activation and matrix protease generation during focal cerebral
ischemia. Stroke 38:646-651. 2007
Adams HP, del Zoppo G,
Alberts MJ, Bhatt DL, Brass L, Furlan A, Grubb RL, Higahsida RT, Jauch
EC, Kidwell C, Lyden PD, Morgenstern LB, Quershi AI, Rosenwasser RH,
Scott PA, Wijdicks EFM. Guidelines for the early management of
adults with ischemic stroke. Stroke 38:1635-1711, 2007.
Milner R, Hung S, Wang X, Berg
GI, Spatz M, del Zoppo GJ. Responses of endothelial cell
and astrocyte matrix integrin receptors to ischemia mimic those
observed in the neurovascular unit. Stroke 39:191-197,
2008
Milner R, Hung S, Wang X, Spatz
M, del Zoppo GJ. The rapid decrease in astrocyte-associated
dystroglycan expression by focal cerebral ischemia is protease
dependent. J. Cereb. Blood Flow Metab. 28:812-823, 2008
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