CURRENT RESEARCH INTERESTS
thrombocytopenic pupura, ADAMTS-13 biology, and platelet functions
under fluid shear stress
Research in our group has been concentrated on platelet functions under
high fluid shear stress. Our aim is to understand how platelets
interact with subendothelium, with each other, and with other blood
cells under flow condition. We are particularly interested in
dissecting signal pathways that are initiated by the interaction of
platelet glycoprotein Ib-IX-V complex and von Willebrand factor.
research also focuses on defining mechanisms through which the
endothelium-derived ultra-large von Willebrand factor multimers are
cleaved by the ADAMTS-13 metalloprotease in vivo and what roles of
this proteolysis process may play in the development of thrombosis.
Such efforts will
allow us to identify agents that selectively block pathophysiological
thrombosis without affecting physioligcal hemostatic function of
Liu, L., Wei, H., Chen, F., Wang, J., Dong, J.F., Zhang, J. (2011) Endothelial progenitor cells correlate with clinical outcome of traumatic brain injury. Critical Care Medicine 39(7):1760-5 (Co-corresponding author).
Liu, M.Y., Zhou, Z., Ma, R., Tao, Z., Choi, H., Bergeron, A.L., Wu, H., Dong, J.F. (2012) Gender-dependent up-regulation of ADAMTS-13 in mice with obesity and hypercholesterolemia. Thromb. Res. 129(4):536-9.
Campos, M., Buchanan, A., Yu, F., Barbalic, M., Xiao, Y., Chambless, L.E., Wu, K.K., Folsom, A.R., Boerwinkle, E., Dong, J.F. (2012) Influence of single nucleotide polymorphisms in factor VIII and von Willebrand factor genes on plasma factor VIII activity: the ARIC study. Blood 119(8):1929-34.
Zhang, J., Jiang, R., Liu, L., Watkins, T., Zhang, F., Dong, J.F. (2012) Traumatic brain injury-associated coagulopathy. J Neurotrauma 29(17):2597-605.
Wang, Q.Y., Song, J., Gibbs, R.A. Boerwinkle, E., Dong, J.F., Yu F.L. (2013) Characterizing polymorphisms and allelic diversity of von willebrand factor gene in the 1000 genomes. J. Thromb Haemost. 11(2):261-9 (Co-Corresponding author).
Zhou, Z., Gushiken, F.C., Bolgiano, D., Salsbery, B.J., Aghakasiri, N., Jing, N., Wu, X., Vijayan, K.V., Rumbaut, R.E., Adachi, R., López, J.A., Dong, J.F. (2013) Signal transducer and activator of transcription 3 (STAT3) regulates collagen-induced platelet aggregation independently of its transcription factor activity. Circulation 127(4):476-85.
Wijeratne S.S., Botello E., Yeh H.J., Zhou Z., Bergeron A., Frey E.W., Patel J.M., Moake J.M., Dong J.F., Kiang C.H. (2013) Force Activation of a Multimeric Adhesive Protein through Domain Conformational Change. Phys. Rev. Lett. 110(10):108102 (Co-Corresponding Author).