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Education and Training:

M.D., Lanzhou Medical School, China (1984)

Resident, Internal Medicine, Tianshuei Medical School, China (1984-85)

Resident, General Surgery, Research Fellow in Neurobiology, Tianshuei Medical School (1985-86)

Resident with research track, Neurosurgery and Neurobiology, Tianjin Medical School, China (1986-89)

M.S., Neurobiology, Tianjin Neurology Institute, Tianjin Medical College (1989)

Neurosurgery Clinical Fellowship, Department of Neurosurgery, University of Birmingham, United Kingdom (1990-93)

Ph.D., Neurobiology, University of  Birmingham/ Wolverhampton, United Kingdom (1993)

Postdoctoral Fellow, Gladstone Institute of Cardiovascular Disease, Cardiovascular Institute, University of California, San Francisco (1993-94)

Jing-fei Dong, M.D., Ph.D
Professor of Medicine
Division of Hematology
University of Washington School of Medicine

Full Member,
Puget Sound Blood Center Research Institute
Office Address:
Puget Sound Blood Center Research Institute

1551 Eastlake Avenue E, Suite 100
Seattle, WA 98102

Phone:   (206) 568-2218
Fax:       (206) 587-6056
E-mail:   jfdong@psbc.org


CURRENT RESEARCH INTERESTS

Thrombotic thrombocytopenic pupura, ADAMTS-13 biology, and platelet functions under fluid shear stress

Traumatic brain injury associated coagulopathy


RESEARCH DESCRIPTION

Research in our group has been concentrated on platelet functions under high fluid shear stress. Our aim is to understand how platelets interact with subendothelium, with each other, and with other blood cells under flow condition. We are particularly interested in dissecting signal pathways that are initiated by the interaction of platelet glycoprotein Ib-IX-V complex and von Willebrand factor.

Our research also focuses on defining mechanisms through which the endothelium-derived ultra-large von Willebrand factor multimers are cleaved by the ADAMTS-13 metalloprotease in vivo and what roles of this proteolysis process may play in the development of thrombosis.

Such efforts will allow us to identify agents that selectively block pathophysiological thrombosis without affecting physioligcal hemostatic function of platelets.


SELECTED PUBLICATIONS

Liu, L., Wei, H., Chen, F., Wang, J., Dong, J.F., Zhang, J. (2011) Endothelial progenitor cells correlate with clinical outcome of traumatic brain injury. Critical Care Medicine 39(7):1760-5 (Co-corresponding author).

Liu, M.Y., Zhou, Z., Ma, R., Tao, Z., Choi, H., Bergeron, A.L., Wu, H., Dong, J.F. (2012) Gender-dependent up-regulation of ADAMTS-13 in mice with obesity and hypercholesterolemia. Thromb. Res. 129(4):536-9.

Campos, M., Buchanan, A., Yu, F., Barbalic, M., Xiao, Y., Chambless, L.E., Wu, K.K., Folsom, A.R., Boerwinkle, E., Dong, J.F. (2012) Influence of single nucleotide polymorphisms in factor VIII and von Willebrand factor genes on plasma factor VIII activity: the ARIC study. Blood 119(8):1929-34.

Zhang, J., Jiang, R., Liu, L., Watkins, T., Zhang, F., Dong, J.F. (2012) Traumatic brain injury-associated coagulopathy. J Neurotrauma 29(17):2597-605.

Wang, Q.Y., Song, J., Gibbs, R.A. Boerwinkle, E., Dong, J.F., Yu F.L. (2013) Characterizing polymorphisms and allelic diversity of von willebrand factor gene in the 1000 genomes. J. Thromb Haemost. 11(2):261-9 (Co-Corresponding author).

Zhou, Z., Gushiken, F.C., Bolgiano, D., Salsbery, B.J., Aghakasiri, N., Jing, N., Wu, X., Vijayan, K.V., Rumbaut, R.E., Adachi, R., López, J.A., Dong, J.F. (2013) Signal transducer and activator of transcription 3 (STAT3) regulates collagen-induced platelet aggregation independently of its transcription factor activity. Circulation 127(4):476-85.

Wijeratne S.S., Botello E., Yeh H.J., Zhou Z., Bergeron A., Frey E.W., Patel J.M., Moake J.M., Dong J.F., Kiang C.H. (2013) Force Activation of a Multimeric Adhesive Protein through Domain Conformational Change. Phys. Rev. Lett. 110(10):108102 (Co-Corresponding Author).