Education and Training:

B.S., Biology, Summa Cum Laude, Loyola University, Chicago, IL (1969)

M.D., University of Chicago, School of Medicine, Chicago, IL (1973)

Internship, University of California, San Francisco, CA (1973-74)

Residency I & 2, University of California, San Francisco, CA (1974-76)

Fellowship, Hematology, University of Washington, Seattle, WA (1976-78)

CURRENT CLINICAL INTERESTS

General hematology/oncology

CURRENT RESEARCH INTERESTS

Inflammation and apoptosis
Cost-effective cancer care, cancer care and training of cancer specialists in resource-limited countries

RESEARCH DESCRIPTION

Role of miRNA-155 in inflammation
Mechanisms of action of extracellular Bcl-2 protein in cytoprotection.

SELECTED PUBLICATIONS (of 175 total research publications)

Vanasse GJ, Winn RK, Rodov S, Zieske AW, Li JT, Tupper JC, Tang J, Raines EW, Peters MA, Yeung KY, Harlan JM.  Bcl-2 Overexpression leads to increases in suppressor of cytokine signaling-3 expression in B cells and De novo Follicular Lymphoma. Mol Cancer Res. 2005; 2:620-31..

A Iwata, V Morgan-Stevenson, B Schwartz, Li Liu, J Tupper, X Zhu, J Harlan*, R Winn. Extracellular BCL2 proteins are danger-associated molecular patterns that reduce tissue damage in murine models of ischemia-reperfusion injury. PLoS ONE 2010:5(2): e9103.
*co-senior and corresponding author

Iwata A, de Claro RA, Morgan-Stevenson VL, Tupper JC, Schwartz BR, Liu L, Zhu X, Jordan KC, Winn RK, Harlan JM.. Extracellular administration of BCL2 protein reduces apoptosis and improves survival in a murine model of sepsis.  PLoS One. 2011; 6(2):e14729. PMID: 21390214.

de Claro RA, Zhu X, Tang J, Morgan-Stevenson V, Schwartz BR, Iwata A, Liles WC, RaineEW, Harlan JM. Hematopoietic Fas Deficiency Does Not Affect Experimental Atherosclerotic Lesion Formation despite Inducing a Proatherogenic State. Am J Pathol. 2011; 178(6):2931-7. PMID: 21550016