Education and Training:

B.A., Carleton College, Northfield, MN (1994)

M.D., University of Minnesota Medical School, Minneapolis, MN (1999)

Residency in Internal Medicine, University of Minnesota, Minneapolis, MN (1992-02)

Fellowship in Hematology (Clinical), University of Washington, Seattle, WA (2004-06)

Fellowship in Hematology (Research), University of Washington, Seattle, WA (2002-03)

CURRENT CLINICAL INTERESTS

Benign red blood cell disorders, iron metabolism (including iron deficiency and hereditary hemochromatosis), acquired aplastic anemia, congenital marrow failure syndromes (including Diamond-Blackfan anemia and Dyskeratosis Congenita) and the transition of care between pediatric and adult hematologists, neurovisceral porphyrias

CURRENT RESEARCH INTERESTS

Normal and ineffective erythropoiesis, systemic and cellular iron homeostasis

RESEARCH DESCRIPTION

The Keel Laboratory aims to understand normal and abnormal red blood cell development.  Current work examines the molecular and cellular events in late-stage erythroid maturation and in particular the mechanisms that coordinate heme synthesis, iron availability, erythropoietin response, and cellular metabolism.

SELECTED PUBLICATIONS

Keel SB, Abkowitz JL.  The microcytic red cell and the anemia of inflammation.  N Engl J Med. 2009 Nov 5;361(19):1904-6.  PMID: 19890136

Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, De Domenico I, Vaughn MB, Kaplan J, Palis J, Abkowitz JL.  A heme export protein is required for red blood cell differentiation and iron homeostasis.  Science. 2008 Feb 8;319(5864):825-8.  PMID: 18258918.

White JG, Keel S, Reyes M, Burris SM.  Alpha-delta storage deficiency in three generations.  Platelets. 2007 Feb;18(1):1-10. PMID: 17365847.

Keel S, Abkowitz JL: Pure red cell aplasia. IN: Clinical Hematology, Young NS, Gerson SL, High KA (eds.), pp 169-180, Philadelphia: Elsevier, 2006.

Keel SB, Phelps S, Sabo KM, O'Leary MN, Kirn-Safran CB, Abkowitz JL. Establishing Rps6 hemizygous mice as a model for studying how ribosomal protein haploinsufficiency impairs erythropoiesis. Exp Hematol. 2012 Apr;40(4):290-4. PMID: 22198155.

Liu L, Sánchez-Bonilla M, Crouthamel M, Giachelli C, and Keel S. Mice lacking the sodium-dependent phosphate import protein, PiT1 (SLC20A1), have a severe defect in terminal erythroid differentiation and early B-cell development. Experimental Hematology, Published online 01 February 2013.