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Education and Training:

B.A., Carleton College, Northfield, MN (1994)

M.D., University of Minnesota Medical School, Minneapolis, MN (1999)

Residency in Internal Medicine, University of Minnesota, Minneapolis, MN (1992-02)

Fellowship in Hematology (Clinical), University of Washington, Seattle, WA (2004-06)

Fellowship in Hematology (Research), University of Washington, Seattle, WA (2002-03)

Sioban B. Keel, M.D.
Assistant Professor of Medicine
Division of Hematology
University of Washington School of Medicine
Office Address:
University of Washington

Division of Hematology
1705 NE Pacific Street
Box 357710, HSB K-136
Seattle, WA 98195-7710
 
Phone:   (206) 685-2196
Fax:       (206) 543-3560
E-mail:   sioban@u.washington.edu

 

CURRENT CLINICAL INTERESTS

Benign red blood cell disorders, iron metabolism (including iron deficiency and hereditary hemochromatosis), acquired aplastic anemia, congenital marrow failure syndromes (including Diamond-Blackfan anemia and Dyskeratosis Congenita) and the transition of care between pediatric and adult hematologists, neurovisceral porphyrias


CURRENT RESEARCH INTERESTS

Normal and ineffective erythropoiesis, systemic and cellular iron homeostasis, and the clinical presentation and molecular underpinnings of inherited marrow failure.


RESEARCH DESCRIPTION

The Keel Laboratory aims to understand normal and abnormal red blood cell development. Current work examines the molecular and cellular events in late-stage erythroid maturation and in particular the mechanisms that coordinate heme synthesis, iron availability, erythropoietin response, and cellular metabolism. A second project in the lab centers on inherited bone marrow failure and inherited myelodysplastic syndromes and aims to define their clinical phenotypes, natural histories, and underlying genetics to improve diagnostic accuracy and clinical care.


SELECTED PUBLICATIONS

Rojek K, Nickels E, Neistadt B, Marquez R, Wickrema A, Artz A, van Besien K, Larson RA, Lee MK, Segal JP, King MC, Walsh T, Shimamura A, Keel SB, Churpek JE, Godley LA. Identifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy. Biol Blood Marrow Transplant. 2016 Nov;22(11):2100-2103. Epub 2016 Aug 4. PMID: 27497531

Keel SB, Scott A, Sanchez-Bonilla M, Ho PA, Gulsuner S, Pritchard CC, Abkowitz JL, King MC, Walsh T, Shimamura A. Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients. Haematologica. 2016 Jul 14. PMID: 27418648

Shemer OS, Keel S, Orly D, Walsh T, Noy-Lotan S, Krasnov T, Yacobovic J, Quarello P, Ramenghi U, MD, King MC, PhD, Shimamura A, MD, Tamary H. Diamond Blackfan Anemia: a Non-Classical Patient with Diagnosis Assisted by Genomic Analysis. Journal of Pediatric Hematology and Oncology June 1 2016 . PMID 27258031

Chen DH, Below JE, Shimamura A, Keel S, Matsushita M, Wolff J, Sul Y, Bonkowski E, Castella M, Taniguchi T, Nickerson D, Papayannopoulou T, Byrd TD, Raskind W. Ataxia-pancytopenia syndrome is caused by missense mutations in SAMD9L. American Journal of Human Genetics 98(6). 1146-1158. PMID 27259050

Yang Z, Keel S, Shimamura A, Liu L, Gerds AT, Li HY, Wood BL, Scott BL Abkowitz JL. Delayed globin synthesis leads to excessive heme and the macrocytic anemia of Diamond Blackfan anemia and del(5q) myelodysplastic syndrome. Science Translational Medicine 338(8). 1-9, 2016. PMID 27169803.

Lewinsohn M, Brown AL, Weinel L, Phung C, Rafidi G, Lee M, Schreiber A, Feng J, Babic M, Chong C, Lee Y, Yong A, Suthers G, Poplawski N, Altree M, Phillips K, Jaensch L, Fine M, D’Andrea R, Lewis I, Medeiros B, Pollyea D, King MC, Walsh T, Keel S, Shimamura A, Godley L, Hahn C, Churpek J, Scott H. Novel germline DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies. Blood 127(8).1017-23, 2016. PMID 26712909.

Gou E, Balwani M, Bissell D, Bloomer J, Bonkovsky H, Desnick R, Naik J, Phillips J, Singal A, Wang B, Keel S, Anderson KE. Pitfalls in erythrocyte protoporphyrin measurement for diagnosis and monitoring of protoporphyrias. Clin Chem. 61(12). 1453-6, 2015. PMID: 26482161.

Doty RT, Phelps S, Shadle C, Sanchez-Bonilla M, Keel S, Abkowitz JL. Coordinate expression of heme and globin is essential for effective erythropoiesis. J Clin Invest. 125(12). 4681-91, 2015. PMID: 26551679.

Keel S, Doty R, Liu L, Nemeth E, Cherian S, et al. Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver. Exp Hematol 43: 469-478, 2015. PMID: 25782630.

Zhang MY, Churpek JE, Keel S, Walsh T, Lee MK et al. Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy. Nature Genetics 46:180-150. 2015. PMID: 25581430.

Zhang MY, Keel SB, Walsh T, Lee MK, Gulsuner S, Watts AC, Pritchard CC, Salipante SJ, Jeng MR, Hofmann I, Williams DA, Fleming MD, Abkowitz JL, King MC, Shimamura A. Genomic analysis of bone marrow failure and myelodysplastic syndromes reveals phenotypic and diagnostic complexity. Haematologica. 2014 Sep 19. pii: haematol.2014.113456. PMID: 25239263

Liu L, Sánchez-Bonilla M, Crouthamel M, Giachelli C, Keel SB. Mice lacking the sodium-dependent phosphate import protein, PiT1 (SLC20A1), have a severe defect in terminal erythroid differentiation and early B-cell development. Exp Hematol. 2013 May;41(5):432-43. PMID: 23376999

Keel SB, Phelps S, Sabo KM, O'Leary MN, Kirn-Safran CB, Abkowitz JL. Establishing Rps6 hemizygous mice as a model for studying how ribosomal protein haplosufficiency impairs erythropoiesis. Exp Hematol. 2012 Apr;40(4):290-4. PMID: 22198155

Keel SB, Abkowitz JL. The microcytic red cell and the anemia of inflammation. N Engl J Med. 2009 Nov 5;361(19):1904-6. PMID: 19890136

Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kinglsey PD, De Domenico I, Vaughn MB, Kaplan J, Palis J, Abkowitz JL. A heme export protein is required for blood cell differentiation and iron homeostasis. Science. 2008 Feb 8;319(5864):825-8. PMID: 18258918

White JG, Keel SB, Reyes M, Burris SM. Alpha-delta storage deficiency in three generations. Platelets. 2007 Feb;18(1):1-10. PMID: 17365847

Keel SB, Abkowitz JL. Pure red cell aplasia. IN: Clinical Hematology, Young NS, Gerson SL, High KA (eds.), pp 169-180, Philadelphia: Elsevier, 2006.