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Education and Training:

B.A., Carleton College, Northfield, MN (1994)

M.D., University of Minnesota Medical School, Minneapolis, MN (1999)

Residency in Internal Medicine, University of Minnesota, Minneapolis, MN (1992-02)

Fellowship in Hematology (Clinical), University of Washington, Seattle, WA (2004-06)

Fellowship in Hematology (Research), University of Washington, Seattle, WA (2002-03)

Sioban B. Keel, M.D.
Assistant Professor of Medicine
Division of Hematology
University of Washington School of Medicine
Office Address:
University of Washington

Division of Hematology
1705 NE Pacific Street
Box 357710, HSB K-136
Seattle, WA 98195-7710
 
Phone:   (206) 685-2196
Fax:       (206) 543-3560
E-mail:   sioban@u.washington.edu

 

CURRENT CLINICAL INTERESTS

Benign red blood cell disorders, iron metabolism (including iron deficiency and hereditary hemochromatosis), acquired aplastic anemia, congenital marrow failure syndromes (including Diamond-Blackfan anemia and Dyskeratosis Congenita) and the transition of care between pediatric and adult hematologists, neurovisceral porphyrias


CURRENT RESEARCH INTERESTS

Normal and ineffective erythropoiesis, systemic and cellular iron homeostasis, and the clinical presentation and molecular underpinnings of inherited marrow failure.


RESEARCH DESCRIPTION

The Keel Laboratory aims to understand normal and abnormal red blood cell development. Current work examines the molecular and cellular events in late-stage erythroid maturation and in particular the mechanisms that coordinate heme synthesis, iron availability, erythropoietin response, and cellular metabolism. A second project in the lab centers on inherited bone marrow failure and inherited myelodysplastic syndromes and aims to define their clinical phenotypes, natural histories, and underlying genetics to improve diagnostic accuracy and clinical care.


SELECTED PUBLICATIONS

Keel SB, Abkowitz JL.  The microcytic red cell and the anemia of inflammation.  N Engl J Med. 2009 Nov 5;361(19):1904-6.  PMID: 19890136

Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, De Domenico I, Vaughn MB, Kaplan J, Palis J, Abkowitz JL.  A heme export protein is required for red blood cell differentiation and iron homeostasis.  Science. 2008 Feb 8;319(5864):825-8.  PMID: 18258918.

 

White JG, Keel SB, Reyes M, Burris SM.  Alpha-delta storage deficiency in three generations.  Platelets. 2007 Feb;18(1):1-10. PMID: 17365847.

 

Keel SB, Abkowitz JL: Pure red cell aplasia. IN: Clinical Hematology, Young NS, Gerson SL, High KA (eds.), pp 169-180, Philadelphia: Elsevier, 2006.

 

Keel SB, Phelps S, Sabo KM, O'Leary MN, Kirn-Safran CB, Abkowitz JL. Establishing Rps6 hemizygous mice as a model for studying how ribosomal protein haploinsufficiency impairs erythropoiesis. Exp Hematol. 2012 Apr;40(4):290-4. PMID: 22198155.

 

Liu L, Sánchez-Bonilla M, Crouthamel M, Giachelli C, and Keel SB. Mice lacking the sodium-dependent phosphate import protein, PiT1 (SLC20A1), have a severe defect in terminal erythroid differentiation and early B-cell development. Experimental Hematology, 2013 May;41(5):432-43. PMID: 23376999.