Education and Training:

M.D., Yale University School of Medicine, New Haven, CT (1995)

Internship: Internal Medicine Training Program, University of Colorado Health Sciences Center, Denver, CO (1996)

Residency: Internal Medicine Training Program, University of Colorado Health Sciences Center, Denver, CO (1998)

Fellowship: Hematology Training Program, University of Washington, Seattle, WA (2003)

CURRENT CLINICAL INTERESTS

General hematology/oncology, coagulopathies, thrombosis

CURRENT RESEARCH INTERESTS

Use of the electronic medical record to improve cancer care

SELECTED PUBLICATIONS

Austin RJ, Kuestner RE, Chang DK, Madden KR, Martin DB. A SILAC compatible strain of Pichia pastoris for expression of isotopically labeled protein standards and quantitative proteomics. J Proteome Res. 2011 Sep 26. [Epub ahead of print] PubMed PMID: 21942632. 

Holstein Sherwood CA, Gafken PR, Martin DB. Collision energy optimization of b- and y-ions for multiple reaction monitoring mass spectrometry. J Proteome Res. 2011 Jan 7;10(1):231-40. Epub 2010 Nov 22. PubMed PMID: 20968307.

Baumgardner LA, Shanmugam AK, Lam H, Eng JK, Martin DB. Fast parallel tandem mass spectral library searching using GPU hardware acceleration. J Proteome Res.  2011 Jun 3;10(6):2882-8. Epub 2011 May 5. PubMed PMID: 21545112; PubMed Central PMCID: PMC3107871.

Amon LM, Law W, Fitzgibbon MP, Gross JA, O'Briant K, Peterson A, Drescher C, Martin DB, McIntosh M. Integrative proteomic analysis of serum and peritoneal fluids helps identify proteins that are up-regulated in serum of women with ovarian cancer. PLoS One. 2010 Jun 15;5(6):e11137. PubMed PMID: 20559444; PubMed Central PMCID: PMC2886122.

Sigmon I, Lee LW, Chang DK, Krusberski N, Cohen D, Eng JK, Martin DB.  ChromEval: a software application for the rapid evaluation of HPLC system performance in proteomic applications. Anal Chem. 2010 Jun 15;82(12):5060-8. PubMed PMID: 20503988.

Sherwood CA, Eastham A, Lee LW, Peterson A, Eng JK, Shteynberg D, Mendoza L, Deutsch EW, Risler J, Tasman N, Aebersold R, Lam H, Martin DB. MaRiMba: a software application for spectral library-based MRM transition list assembly. J Proteome Res. 2009 Oct;8(10):4396-405. PubMed PMID: 19603829; PubMed Central PMCID: PMC2837355.

Sherwood CA, Eastham A, Lee LW, Risler J, Vitek O, Martin DB. Correlation between y-type ions observed in ion trap and triple quadrupole mass spectrometers. J Proteome Res. 2009 Sep;8(9):4243-51. PubMed PMID: 19603825; PubMed Central PMCID: PMC2802215.

Peterson A, Hohmann L, Huang L, Kim B, Eng JK, Martin DB. Analysis of RP-HPLC loading conditions for maximizing peptide identifications in shotgun proteomics.  J Proteome Res. 2009 Aug;8(8):4161-8. PubMed PMID: 19601632; PubMed Central PMCID: PMC2757279.

Sherwood CA, Eastham A, Lee LW, Risler J, Mirzaei H, Falkner JA, Martin DB. Rapid optimization of MRM-MS instrument parameters by subtle alteration of precursor and product m/z targets. J Proteome Res. 2009 Jul;8(7):3746-51. PubMed PMID: 19405522; PubMed Central PMCID: PMC2811718.

Hohmann L, Sherwood C, Eastham A, Peterson A, Eng JK, Eddes JS, Shteynberg D, Martin DB. Proteomic analyses using Grifola frondosa metalloendoprotease Lys-N. J Proteome Res. 2009 Mar;8(3):1415-22. PubMed PMID: 19195997; PubMed Central PMCID: PMC2798736.

Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB, Tewari M. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8. PubMed PMID: 18663219; PubMed Central PMCID: PMC2492472.

Martin DB, Holzman T, May D, Peterson A, Eastham A, Eng J, McIntosh M. MRMer, an interactive open source and cross-platform system for data extraction and visualization of multiple reaction monitoring experiments. Mol Cell Proteomics. 2008 Nov;7(11):2270-8. PubMed PMID: 18641041; PubMed Central PMCID: PMC2577205.

Hohmann LJ, Eng JK, Gemmill A, Klimek J, Vitek O, Reid GE, Martin DB. Quantification of the compositional information provided by immonium ions on a quadrupole-time-of-flight mass spectrometer. Anal Chem. 2008 Jul 15;80(14):5596-606. PubMed PMID: 18564857; PubMed Central PMCID: PMC2638499.

Klimek J, Eddes JS, Hohmann L, Jackson J, Peterson A, Letarte S, Gafken PR, Katz JE, Mallick P, Lee H, Schmidt A, Ossola R, Eng JK, Aebersold R, Martin DB.  The standard protein mix database: a diverse data set to assist in the production of improved Peptide and protein identification software tools. J Proteome Res. 2008 Jan;7(1):96-103. PubMed PMID: 17711323; PubMed Central PMCID: PMC2577160.

Dall'Era MA, Oudes A, Martin DB, Liu AY. HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells. Prostate. 2007 May 15;67(7):714-21. PubMed PMID: 17342744.

Martin DB, Eng JK, Nesvizhskii AI, Gemmill A, Aebersold R. Investigation of neutral loss during collision-induced dissociation of peptide ions. Anal Chem. 2005 Aug 1;77(15):4870-82. PubMed PMID: 16053300; PubMed Central PMCID: PMC1360221.

Martin DB, Gifford DR, Wright ME, Keller A, Yi E, Goodlett DR, Aebersold R, Nelson PS. Quantitative proteomic analysis of proteins released by neoplastic prostate epithelium. Cancer Res. 2004 Jan 1;64(1):347-55. PubMed PMID: 14729644.

Zhang H, Li XJ, Martin DB, Aebersold R. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. Nat Biotechnol. 2003 Jun;21(6):660-6 PubMed PMID: 12754519.