CURRENT CLINICAL INTERESTS
Hematopoietic stem cell donation by unrelated donors
Research on neutrophil preservation and function, apheresis, hematopoietic growth factors in transfusion medicine
The laboratory is involved in a multicenter Phase I/II study on the use of granulocytes obtained from normal donors stimulated with G-CSF and dexamethasone to treat patients with neutropenia and documented bacterial or fungal infection. Goals are to determine the feasibility of using community donors for stimulated granulocyte collections, the yields obtainable using this strategy, the hematological response in recipients, adverse effects in both donors and recipients, and whether or not the infused cells are able to function in the recipients. Controlled randomized trials will follow these studies if warranted by the data.
Studies in progress to determine the viability and storage characteristics of neutrophils collected from normal subjects stimulated with G-CSF.
We have also been active in the evaluation of new apheresis equipment and the optimization of platelet and neutrophil yields using these machines.
Evaluation of adverse effects experienced by hematopoietic stem cell donors under the National Marrow Donor Program.
Price TH, Ochs HD, Gershoni-Baruch R, Harlan JM, Etzioni A: In vivo neutrophil and lymphocyte function studies in a patient with leukocyte adhesion deficiency type II.
Blood 84:1666-72, 1994.
Price TH, Goodnough LT, Vogler WR, Sacher RA, Hellman RM, Johnston MFM, Bolgiano DC, Abels RI: The effect of human erythropoietin on the efficacy of autologous blood donation in patients with low hematocrits: A multicenter randomized double-blind controlled trial.
Transfusion 36:29-36, 1996.
Price TH, Chatta GS, Dale DC: The effect of recombinant granulocyte colony-stimulating factor on neutrophil kinetics in normal young and elderly humans.
Blood 88:335-340, 1996.
Price TH: The current prospects for neutrophil transfusions for the treatment of granulocytopenic infected patients.
Trans. Med. Rev. 14(1):2-11, 2000.
Price TH, Bowden RA, Boechkh M, Bux J, Nelson K, Liles WC, and Dale DC: Phase I/II trial of neutrophil transfusions from donors stimulated with
G-CSF and dexamethasone for treatment of patients with infections in hematopoietic stem cell transplantation.
Blood 95:3302-3309, 2000.