Education and Training:
A.B., Biochemistry, Princeton University, Princeton, NJ (1983)
M.S., Biology, University of Rochester, Rochester, NY (1988)
Ph.D., Biology, University of Rochester, Rochester, NY, (1990)
M.D. University of Rochester, Rochester, NY (1991)
Internship in Pediatrics, Johns Hopkins Hospital, Baltimore, MD (1991-92)
Residency in Pediatrics, Johns Hopkins Hospital, Baltimore, MD (1992-94)
Fellow, Pediatric Hematology/Oncology, Dana Farber Cancer Institute and Children's Hospital,
Boston, MA (1994-97)
Posdoctoral Physician Fellow, Howard Hughes Medical Institute (1997-00)
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Akiko Shimamura, M.D., Ph.D.
Associate Professor of Pediatrics/Hematology-Oncology
Adjunct Associate Professor of Medicine/Hematology
University of Washington School of Medicine
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Office Address:
Fred Hutchinson Cancer Research Center
FHCRC Box 358080, MS D2-100
PO Box 19024
Seattle, WA 98109-1024
Phone: (206) 667-11272
Seattle Children's
B-6553 Hematology-Oncology
4800 Sand Point Way NE
Seattle, WA 98105
Phone: 206-987-2106
E-mail: ashimamu@fhcrc.org
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Current Clinical Interests
Inherited bone marrow failure syndromes and aplastic anemia
Swachman-Diamond syndrome, Fanconi anemia and Diamond Blackfan anemia
Research Interests
Hematopoiesis and leukemogenesis
Research Description
My research interests focus on hematopoiesis and
leukemogenesis in the inherited marrow failure syndrome. My current
studies investigate the role of ribosomal dysfunction in marrow
failure and malignant transformation. I am also pursuing studies on
translational control of gene expression in hematopoietic stem cells.
Recent laboratory findings reported a role for mitotic spindle
stabilization in genomic instability. I am a member of the scientific
advisory board for the Shwachman-Diamond Syndrome Foundation and
served as co-chair of the Fourth International Scientific Congress on
Shwachman-Diamond Syndrome. I am also the principal investigator for
the North American Shwachman-Diamond Syndrome Registry currently under
development.
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Selected Publications
Cantor AB, Shimamura A. Cellular basis of
hematopoiesis and marrow failure syndromes. In: Kahn MJ, Gregory SA,
eds. American Society of Hematology Self-Assessment Program (ASH-SAP),
Third Edition. Washington, D.C.: American Society of Hematology. 2007.
Ganapathi KA, Austin KM, Lee CS, Dias A, Malsch MM, Reed R, Shimamura
A. The human Shwachman-Diamond syndrome protein, SBDS, associates
with ribosomal RNA. Blood. Sept 2007;110(5):1458-1465.
Kennedy RD, Chen CC, Stuckert P, Archila EM, De la Vega MA, Moreau L,
Shimamura A, D'Andrea AD. Fanconi anemia pathway-deficient tumor cells
are hypersensitive to inhibition of ataxia telangiectasia mutated. J
Clin Invest. May 2007;117(5):1440-1449
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