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Education and Training:

B.A., Mathematics, Cum Laude, Washington State University, Pullman, Washington (1959)

M.D., George Washington University, Washington, DC (1963)

Rotating Internship, Mount Sinai Hospital, New York, New York (1963-64)

Resident in Medicine, Mount Sinai Hospital, New York, New York (1964-65)

Resident in Medicine,
Parkland Memorial Hospital, Dallas, TX (1965-67)

Senior Fellow in Medicine (Hematology/Oncology), University of Washington, Seattle, WA (1967-68)

Sherrill J. Slichter, M.D.
Professor of Medicine, Division of Hematology
University of Washington School of Medicine

Director, Platelet Transfusion Research,
Bloodworks NW

Office Address:
Bloodworks NW
Box 359190
921 Terry Avenue
Seattle, WA 98104-1256

Phone:   (206) 292-6541
Fax:       (866) 287-7209
E-mail:   sherrills@BloodworksNW.org


CURRENT CLINICAL INTERESTS


Evaluate whether pathogen reduction will allow extension of the storage time of platelets and whether it will also prevent alloimmunization to platelets when combined with filter-leukoreduction of platelets.


CURRENT RESEARCH INTERESTS

  • Evaluate methods of extending platelet storage times;

  • Assess viability and function of new platelet products; i.e., cryopreserved platelets, cold stored platelets, and lyophilized platelets;

  • Initiate a large hematology/oncology patient transfusion trial of pathogen reduced platelets.

RESEARCH DESCRIPTION

Evaluate Methods Of Extending Platelet Storage Times: Currently, platelets can be stored for only 5 days at room temperature (22°C). As it is not feasible to completely sterilize the venipuncture site, it is always possible that bacteria may enter the stored platelets resulting in an infectious risk to transfused thrombocytopenic patients. To extend storage beyond 5 days, it is very likely that the Food and Drug Administration (FDA) will require a pathogen reduction process. As pathogen reduction reduces platelet viability, we are conducting studies to determine how long pathogen reduced platelets can be stored and still meet FDA’s post-storage viability criteria.

Assess Viability And Function Of New Platelet Products:
  • Cryopreserved Platelets: We have completed of a dose response safety study of cryopreserved platelets given to thrombocytopenic hematology/oncology patients. Our next study will be an efficacy study comparing bleeding outcomes in cardiac surgery patients.who are randomized to receive either standard platelets or cryopreserved platelets.

  • Cold Stored Platelets: It is very difficult to supply platelet products to far-forward combat casualty care facilities. It has been known since the 1970’s that 22°C and 4°C stored platelets have almost the same post-transfusion platelet increments but platelet survivals are much better for 22°C stored platelets; i.e., approximately 5 days versus 1 day, respectively, in normal subjects given their autologous radiolabeled 3-day 4°C or 22°C stored platelets. To decrease transfusion frequency for hematology/oncology patients, blood centers routinely store platelets at 22°C. However, to maintain hemostasis long enough for wound repair, platelet survivals of only several hours may be needed. We are determining how long platelets can be stored at 4°C and maintain adequate post-storage viability and function.

  • Lyophilized Platelets: Lyophilized platelets can be stored in small bottles on a shelf for periods of a year or more. We are currently doing a “first in human” dose response safety study of autologous lyophilized platelets given to normal subjects. If safety is demonsrated, follow-on studies will be radiolabeled autologous lyophilized platelet studies to determine recovery and survival kinetics and, finally, transfusion studies to determine hemostatic efficacy in patients who need platelet transfusions.

Initiate A Large Hematology/Oncology Transfusion Trial Of Pathogen Reduced Platelets in Patients: Currently, there is only one FDA licensed pathogen reduction process for platelets. However, there is another pathogen reduction process that is licensed in Europe but not in the U.S. I will be the principal investigator for a large multi-institutional 600 patient licensing trial to assess the safety and efficacy of the other pathogen reduction process. The primary endpoint will be days of bleeding in hematology/oncology patients randomized to standard or pathogen reduced platelets. The major secondary endpoint will be the rates of alloimmunization to platelets. In our dog platelet transfusion model, we have shown that leukoreduced/pathogen reduced platelets are 97% effective in preventing alloimmunization to donor platelets. This trial will allow us to determine whether leukoreduced/pathogen reduced platelets are similarly effective in patients.


SELECTED PUBLICATIONS

Slichter SJ, Fish D, Abrams VK, Gaur L, Nelson K, Bolgiano D. Evaluation of different methods of leukoreduction of donor platelets to prevent alloimmune platelet refractoriness and induce tolerance in a canine transfusion model. Blood 2005;105(2):847-854.

Slichter SJ, Davis K, Enright H, Braine H, Gernsheimer T, Kao KJ, Kickler T, Lee E, McFarland J, McCullough J, Rodey G, Schiffe r C, Woodson R. Factors affecting post-transfusion platelet increments, platelet refractoriness, and platelet transfusion intervals in thrombocytopenic patients. Blood 2005;105(10):4106-4114.

Slichter SJ, Kaufman R, Assmann SF, McCullough J, Triulzi DJ, Strauss RG, Gernsheimer TB, Ness PM, Brecher ME, Josephson CD, Konkle BA, Woodson RD, Ortel TL, Hillyer CD, Skerrett DL, McCrae KR, Sloan SR, Uhl L, George JN, Aquino VM, Manno C, McFarland JG, Hess JR, Leissinger C, Granger S. Dose of prophylactic platelet transfusions and prevention of hemorrhage. N Engl J Med 2010;362(7):600-613.

Slichter SJ, Bolgiano D, Kao K-J, Kickler TS, McFarland J, McCullough J, Woodson R. Persistence of lymphocytotoxic antibodies in patients in the Trial to Reduce Alloimmunization to platelets: Implications for using modified blood products. Transfus Med Rev 2011;25(2):102-110.

Slichter SJ, Bolgiano D, Corson J, Jones MK, Christoffel T. Extended storage of platelet-rich plasma prepared platelet concentrates in plasma or Plasmalyte. Transfusion 2010;50(10);2199-2209.

Dumont LJ, Dumont DF, Unger ZM, Siegel A, Szczepiorkowski ZM, Corson JS, Jones MK, Christoffel T, Pellham E, Bailey SL, Slichter SJ; for the BEST Collaborative. A randomized controlled trial comparing autologous radiolabeled in vivo platelet recoveries and survivals of 7-day stored platelet-rich plasma and buffy coat platelets from the same subjects. Transfusion 2011;51(6):1241-1248.

Slichter SJ. New thoughts on the correct dosing of prophylactic platelet transfusions to prevent bleeding. Curr Opin Hematol. 2011;18(6):427-435.

Schubert P, Culibrk B, Karwal S, Slichter SJ, Devine DV. Optimization of platelet concentrate quality: Application of proteomic technologies to donor management. J Proteomics 2012;76:329-336.

Slichter SJ, Pellham E, Bailey SL, Christoffel T. Filtration leukoreduction followed by pathogen-reduction (Mirasol treatment) prevents alloimmune platelet refractoriness in a dog platelet transfusion model. Blood 2012;120(21):271.

Slichter SJ, Bolgiano D, Corson J, Jones MK, Christoffel T, Pellham E. Extended storage of apheresis platelets in plasma. Vox Sang 2013;104(4):324-330.

Slichter SJ. Eliminate prophylactic platelet transfusions? Invited Editorial. N Engl J Med 2013;368(19):1837-1838.

Slichter SJ, Corson J, Jones MK, Christoffel T, Pellham E, Bailey SL, Bolgiano D. Exploratory studies of extended storage of apheresis platelets in a platelet additive solution (PAS). Blood 2014;123(2):271-280.

Slichter SJ, Bolgiano D, Corson J, Jones MK, Christoffel T, Bailey SL, Pellham E. Extended storage of buffy coat platelet concentrates in plasma or a platelet additive solution. Transfusion 2014;54(9):2283-2291.

Zimring JC, Slichter S, Odem-Davis K, Felcyn JR, Kapp LM, Bell LN, Gunst PR, Corson J, Jones MK, Pellham E, Bailey SL, Fu X. Metabolites in stored platelets associated with platelet recoveries and survivals. Transfusion 2016 Aug;56(8):1974-1983.