Funded by the Centers for
Disease Control and Prevention
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FIB-4: The FIB-4 score is a non-invasive scoring system to estimate a patient's degree of hepatic fibrosis and it is based on age, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and platelet count. The FIB-4 score is calculated as follows :
Age (years) X AST (IU/L)
Platelet count (platelets x109/L) X √ ALT
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FibroScan: An office-based instrument that uses an ultrasound-based technique called transient elastrography to measure the speed through which elastic shock waves pass through the liver. This speed correlates directly with liver stiffness; fibrotic livers generate higher FibroScan readings. This test has been validated across multiple patient populations including viral hepatitis but is not currently available in the U.S.
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FibroTest: A blood test comprised of five different serum biochemical serum markers (alpha-2-macroglobulin, apolipoprotein A1, haptoglobin, γ-glutamyltranspeptidase, and bilirubin) that are associated with hepatic fibrosis. It is one of the more widely used non-invasive assays for hepatic fibrosis.