Funded by the Centers for
Disease Control and Prevention
- Necroinflammatory activity: Reflects the degree of inflammation and necrosis seen on liver biopsy in a patient with chronic viral hepatitis – the severity of this activity is characterized by a scoring system (Ishak, Knodell, Metavir are examples). Necroinflammatory activity is one of the main predictors of liver disease outcome in hepatitis B; patients with a high activity score are at greater risk of rapid progression of fibrosis and cirrhosis.
- Nonresponder: A patient who has failure of the HCV RNA level to drop to undetectable by week 24 of therapy. Nonresponders include partial responders and null responders.
- Null Responder: A patient who has an HCV RNA level decrease of less than 2 log10 IU/ml from baseline by week 12 of treatment. The null response is considered a type of nonresponse.