Postexposure Prophylaxis after Exposure to Hepatitis A Virus

You answered:

A Administer hepatitis A vaccine.

This answer is correct. Historically, only immune globulin (IG) was recommended for postexposure prophylaxis after exposure to HAV.  In 2007, however, the ACIP issued guidelines that recommended hepatitis A vaccine for hepatitis A postexposure prophylaxis in healthy persons aged 12 months-40 years of age. For some patient populations, such as immunocompromised individuals, the use of IG is still preferred for hepatitis A postexposure prophylaxis. For the exposed individual in this case, the HAV vaccine should be given as soon as possible and not more than 2 weeks after the exposure.  The patient’s last exposure was within the previous 10 days (as measured from the time of onset of his housemate’s symptoms). This patient also needs to complete the hepatitis A vaccine series to provide long-term protection against future infection, because men who have sex with men are at increased risk for acquiring HAV infection.


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