Hepatitis A Vaccination
||All susceptible travelers who plan to depart for an area endemic for hepatitis A in less
than 2 weeks should receive immune globulin as well as hepatitis A vaccine.
This answer is incorrect. Historically, the Advisory Committee on Immunization
Practices (ACIP) recommended administering hepatitis A vaccination to susceptible travelers at least 2-4 weeks
before departure to endemic areas. Travelers who were leaving in less than 2 weeks were advised to receive immune
globulin for short-term protection. However, based on data that showed comparable postexposure efficacy of vaccine
and immune globulin among healthy persons aged 1-40 years, a single-dose of vaccine administered before departure
is now considered adequate protection for most healthy persons. Those travelers departing in less than 2 weeks
who should receive immune globulin include persons at risk for severe hepatitis A: adults older than 40 years
such as our patient and persons with chronic liver disease or other chronic medical conditions.
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