Serologic and Virologic Markers of Hepatitis B Virus Infection

You answered:

B HBsAg (+), anti-HBs (-), Total anti-HBc (-), HBeAg (-), anti-HBe (+).

This answer is incorrect. The absence of total anti-HBc makes this profile inconsistent with either acute or chronic infection. The anti-HBc is the first antibody to develop and typically remains positive for life. This profile is not consistent with acute HBV infection since patients with acute HBV infection should have a positive test for both anti-HBc and HBeAg. Although this profile has some features (presence of HBsAg and absence of anti-HBs) that make it consistent with chronic HBV infection, patients with chronic HBV infection should have a positive total anti-HBc test. Although most patients with chronic HBV infection may have persistent HBeAg in the blood, some have no detectable HBeAg.

A HBsAg (-), anti-HBs (+), Total anti-HBc (+), HBeAg (-), anti-HBe (+).
C HBsAg (+), anti-HBs (-), Total anti-HBc (+), HBeAg (+), anti-HBe (-).
D HBsAg (-), anti-HBs (+), Total anti-HBc (-), HBeAg (-), anti-HBe (-).

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