Antiviral Agents Used to Treat Hepatitis B Virus Infection

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A A major drawback for the use of peginterferon alfa-2a (Pegasys) is the rapid development of HBV resistance.

This answer is incorrect. Pegylated interferon therapy, unlike the oral antiviral agents, has not been shown to be associated with the development of hepatitis B virus resistance. The major drawback for peginterferon alfa-2a therapy is the multiple side effects, such as fatigue, anorexia, influenza-like symptoms, and cytopenias.

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B Telbivudine (Tyzeka) and lamivudine (Epivir-HBV) are both L-nucleoside analogues that share cross-resistance.
C Tenofovir (Viread) should not be considered an option for this patient because of the unacceptably high incidence of tenofovir-induced renal failure in Asian patients.
D The same dose of entecavir (Baraclude) can be used for treatment-naïve patients and lamivudine-resistant patients.

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