Antiviral Agents Used to Treat Hepatitis B Virus Infection

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D The same dose of entecavir (Baraclude) can be used for treatment-naïve patients and lamivudine-resistant patients.

This answer is incorrect. The degree and durability of entecavir’s efficacy are diminished in patients who are refractory or resistant to lamivudine. The recommended once daily 0.5 mg dose for treatment-naïve patients should be increased to 1.0 mg once daily in patients with prior resistance to lamivudine.

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A A major drawback for the use of peginterferon alfa-2a (Pegasys) is the rapid development of HBV resistance.
B Telbivudine (Tyzeka) and lamivudine (Epivir-HBV) are both L-nucleoside analogues that share cross-resistance.
C Tenofovir (Viread) should not be considered an option for this patient because of the unacceptably high incidence of tenofovir-induced renal failure in Asian patients.

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