Choosing an Antiviral Agent for Initial Treatment of Hepatitis B Virus Infection

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C Peginterferon alfa-2a (Pegasys) should be used with caution in this patient given the possibility of hepatic decompensation with an immune-mediated flare during therapy.

This answer is correct. Peginterferon has been used safely in patients with compensated cirrhosis, but it should be used with caution and with close monitoring of liver function in patients with cirrhosis, given the possibility of immune-mediated hepatitis flares and hepatic decompensation on therapy.

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