Choosing an Antiviral Agent for Initial Treatment of Hepatitis B Virus Infection
Last updated: January 25, 2010
A 45-year-old Cambodian man with HBeAg-negative chronic hepatitis B presents for evaluation. He has had serum alanine aminotransferase (ALT) levels of 60-80 U/L and HBV DNA level of 30,000 IU/mL. He has no history of ascites or encephalopathy and laboratory studies are unremarkable, including a normal serum albumin and total bilirubin level. An abdominal ultrasound shows a nodular liver without signs of portal hypertension, findings consistent with compensated cirrhosis. He has never received therapy for hepatitis B.
Which of the following statements is TRUE regarding the choice of available therapeutic agents for patients with chronic hepatitis B infection?