Approach to HBeAg-Negative Patients with Increased Hepatic Aminotransferase Levels
This answer is incorrect. Hepatitis B virus can be divided into 7 genotypes, genotypes A-G. The prevalence of these genotypes differs geographically, with Genotypes A and G being most common in North America and Western Europe. Mutations in the precore and core promoter regions occur more commonly in patients with non-A genotypes, but a diagnosis of HBeAg-negative chronic hepatitis B cannot be made by genotyping alone. Rather, the diagnosis is made by demonstrating high HBV DNA loads (greater than 104 copies/ml) in an HBsAg-positive, HBeAg-negative patient.
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