Management of Patients with Chronic Hepatitis B and Antiviral Resistance

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B The patient would likely have a good response with the addition of adefovir (Hepsera) 10 mg once daily or tenofovir (Viread) 300 mg once daily.

This answer is correct. In cases where lamivudine resistance has developed, studies have shown that adding adefovir or tenofovir results in high rates of viral suppression. In addition, available data suggest adding adefovir or tenofovir, rather than switching to adefovir or tenofovir, is a superior strategy.


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