Management of Treatment-Naïve Genotypes 2 and 3 HCV Infection

You answered:

B Treatment with peginterferon and ribavirin should last 48 weeks to optimize response rates in genotype 2.

This answer is incorrect. Treatment with peginterferon and ribavirin for 48 weeks is excessive; studies have shown that a 24-week duration is comparable to a 48-week duration for genotype 2 infection.

A HCV genotype 2 infection is generally associated with higher sustained virologic response rates compared with other HCV genotypes.
C Weight-based dosing of ribavirin is mandatory for optimal response with genotype 2.
D The recommended duration of therapy for HCV genotype 2 infection with peginterferon and ribavirin is 12 weeks.

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