Management of Treatment-Naïve Genotypes 2 and 3 HCV Infection

Author: Jennifer C. Ling, MD H. Nina Kim, MD, MSc

Last updated: July 9, 2013

A 55-year-old man presents for evaluation of his hepatitis C (HCV). He feels well and denies any history of gastrointestinal bleeding, encephalopathy, or abdominal swelling. His serum aminotransferase levels (ALT and AST) are 3 to 4 times greater than the upper limits of normal. Serum albumin, total bilirubin, alkaline phosphatase, and prothrombin time all are normal. Further testing reveals a HCV RNA level of 3 million IU/ml and HCV genotype 2 infection.

Which of the following statements is TRUE regarding therapy in such cases?

A HCV genotype 2 infection is generally associated with higher sustained virologic response rates compared with other HCV genotypes.
B Treatment with peginterferon and ribavirin should last 48 weeks to optimize response rates in genotype 2.
C Weight-based dosing of ribavirin is mandatory for optimal response with genotype 2.
D The recommended duration of therapy for HCV genotype 2 infection with peginterferon and ribavirin is 12 weeks.