Medications Used in Hepatitis C Treatment

Author: H. Nina Kim, MD, MSc Margaret C. Shuhart, MD, MS

Last updated: March 11, 2013

A 42-year-old man with chronic hepatitis C infection is interested in starting hepatitis C treatment. Prior testing revealed genotype 1 hepatitis C virus with a baseline hepatitis C virus (HCV) RNA level of 220,000 IU/ml. A recent liver biopsy demonstrated stage 2 of 4 fibrosis by Metavir scoring. The decision is made to initiate hepatitis C therapy with peginterferon alfa and ribavirin and one of the hepatitis C protease inhibitors.

Which of the following statements is correct regarding the medications used to treat genotype 1 HCV infection?

A The patient should receive ribavirin as a fixed dose of 800 mg per day in this regimen.
B Uncontrolled systemic lupus erythematosus is a contraindication to treatment with peginterferon.
C Thrombocytopenia is the most common cytopenia attributable to the hepatitis C protease inhibitors.
D Telaprevir is dosed three times daily and must be taken on an empty stomach.