Virologic Responses during Treatment of Hepatitis C

Author: H. Nina Kim, MD, MSc David H. Spach, MD

Last updated: October 1, 2012

A 48-year-old man with genotype 1 chronic hepatitis C virus (HCV) infection presents for a follow-up evaluation to discuss retreatment of his HCV. He has a history of past treatment with peginterferon and ribavirin. During treatment, his HCV RNA level decreased from 4.5 million IU/ml to 4,000 IU/ml at week 4 and became undetectable (less than 25 IU/ml) at week 12. The HCV RNA level remained undetectable for the remainder of the 48-week treatment course. He experienced some anemia during the second half of his course that required dose reduction of his ribavirin. At 24 weeks after the end of treatment, his HCV RNA returned at 310,000 IU/ml.

Which one of the following statements regarding this patient is correct regarding the patient's prior response to dual therapy with peginterferon and ribavirin?

A The patient experienced a partial response.
B The patient experienced a virologic relapse.
C The patient experienced a rapid virologic response.
D The patient experienced a null response.