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UW Virology Research ClinicPublications

General Information
Detection and Testing
Immunology
Viral Shedding
Treatment
Transmission
Pregnancy
Vaccines
HIV/HSV

 

General Information

HSV-2 serologic testing in an HMO population: uptake and psychosocial sequelae
Genital herpes in a primary care clinic: demographic and sexual correlates of herpes simplex type 2 infection
Herpes simplex virus type 2 serological testing and psychosocial harm: a systematic review
Epidemiology, clinical presentation, and antibody response to primary infection with herpes simplex virus type 1 and type 2 in young women
Evidence of latency and reactivation of both herpes simplex virus (HSV-1) and HSV-2 in the genital region
APOE genotype is associated with oral herpetic lesions but not genital or oral herpes simplex virus shedding
The effects of daily distress and personality on genital HSV shedding and lesions in a randomized, double-blind, placebo-controlled, crossover trial o
An interactive, computer-based program to educate patients about genital herpes
Herpes simplex virus viremia during primary genital infection
Genital HSV-1 infections

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Detection and Testing

Serologic Testing for HSV-1 and HSV-2 Infection
Knowledge Is Power: A Case for Wider Herpes Simplex Virus Serologic Testing (public preview, subscription required)
Genital herpes: review of the epidemic and potential uses of type-specific serology
Premarket evaluation of the POCkit TM HSV-2 type specific serologic test in culture-documented cases of HSV-2

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Immunology

Peripheral blood CD4 T-cell and pDC reactivity to HSV-2 and pDC number do not correlate with the severity of recurrent genital herpes
Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection (public preview, subscription required)
Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract
Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition
Evasion of the mucosal innate immune system by herpes simplex virus type 2
Detailed characterization of T cell responses to herpes simplex virus-2 in immune seronegative persons
Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes
An effector phenotype of CD8+ T cells at the junction epithelium during clinical quiescence of herpes simplex virus 2 infection

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Viral Shedding

Genital Shedding of Herpes Simplex Virus Among Symptomatic and Asymptomatic Persons With HSV-2 Infection
Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults
Oral shedding of herpes simplex virus type 2
Frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model
Overlapping reactivations of herpes simplex virus type 2 in the genital and perianal mucosa
Persistent genital herpes simplex virus-2 shedding years following the first clinical episode
Frequent genital HSV-2 shedding in immunocompetent women
Virologic characteristics of subclinical and symptomatic genital herpes infections
The kinetics of mucosal herpes simplex virus-2 infection in humans: evidence for rapid viral-host interactions

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Treatment

Helicase-Primase Inhibitor Pritelivir for HSV-2 Infection (free preview, must subscribe for full access)
A pooled analysis of the effect of condoms in preventing HSV-2 acquisition
Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials
Case-crossover analysis of condom use and herpes simplex virus type 2 acquisition
Rapid viral expansion and short drug half-life explain the incomplete effectiveness of current Herpes Simplex Virus-2 directed antiviral agents
One-day regimen of valacyclovir for treatment of recurrent genital herpes simplex virus 2 infection
Valacyclovir and acyclovir for suppression of shedding of herpes simplex virus in the genital tract
Famciclovir Reduces Viral Mucosal Shedding in HSV-Seropositive Persons
New therapies and prevention strategies for genital herpes
Suppression of subclinical shedding of herpes simplex virus type 2 with acyclovir

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Transmission

HSV-2 transmission probability estimates (click for full text)
Knowledge of partners' genital herpes protects against herpes simplex virus type 2 acquisition
Once-daily valacyclovir to reduce the risk of transmission of genital herpes
Effect of condoms on reducing the transmission of herpes simplex virus type 2 from men to women
The relationship between condom use and herpes simplex virus acquisition

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Pregnancy

Maternal and neonatal herpes simplex virus infections
Genital HSV detection among HIV-1-infected pregnant women in labor
A prospective cohort study of partner testing for herpes simplex virus and sexual behavior during pregnancy
Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant
Preventing herpes simplex virus transmission to the neonate
Neonatal herpes simplex virus infection in relation to asymptomatic maternal infection at the time of labor

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Vaccines

Current status and prospects for development of an HSV vaccine
Population level impact of an imperfect prophylactic vaccine for herpes simplex virus-2
Vaxfectin-adjuvanted plasmid DNA vaccine improves protection and immunogenicity in a murine model of genital herpes infection
Phase I dose-escalation study of a monovalent heat shock protein 70-herpes simplex virus type 2 (HSV-2) peptide-based vaccine designed to prime or boo
Immunotherapy of recurrent genital herpes with recombinant herpes simplex virus type 2 glycoproteins D and B: results of a placebo-controlled trial
Efficacy results of a trial of a herpes simplex vaccine
Safety and immunogenicity of long HSV-2 peptides complexed with rhHsc70 in HSV-2 seropositive persons

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HIV/HSV

High-dose valacyclovir decreases plasma HIV-1 RNA more than standard-dose acyclovir in persons coinfected with HIV-1 and HSV-2: a randomized crossover
Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study
Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa
Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2
Rapidly cleared episodes of oral and anogenital herpes simplex virus shedding in HIV-infected adults
The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics
Severe genital herpes infections in HIV-infected individuals with impaired herpes simplex virus specific CD8 + cytotoxic T lymphocytes responses
Frequent recovery of HIV from genital herpes simplex virus lesions in HIV infected persons
Frequency of symptomatic and asymptomatic HSV-2 reactivations among HIV-infected men

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