The purpose of this study is to assess the effectiveness of hydroxychloroquine (HCQ) or HCQ/azithromycin for the treatment of SARS-CoV-2 infection (the virus that causes COVID-19) in those adults who have been diagnosed with the virus. We plan on enrolling 635 participants from sites all over the country.

Eligible participants will be randomly assigned to receive either HCQ and folic acid, HCQ and azithromycin, or ascorbic acid (Vitamin C) and folic acid for 10 days. All participants in one household will receive the same intervention. Study will last 28 days and will include no in-person visits. All contact will be completed through HIPAA compliant video-conference (telehealth).

Participants will be asked to collect daily mid-nasal swabs, complete a twice daily survey, collected vitals twice a day, and take their assigned medicals twice a day. Participants will receive a schedule outlining the activities. Most activities will take place  during the first 14 days of the study. After enrollment, there will be 4 follow-up visits. All will be via Telehealth or phone. At various timepoints during the study, swab pick-up will be arranged via courier. Participants will be offered participation into an optional sub-study that involves the collection of a dried blood samples.

Participants will be compensated $200 for the 28-day study.