Immunogenicity of fractional dose of the HPV vaccines
Fractional Dose of the HPV Vaccine
The University of Washington is seeking volunteers for an open-label, randomized trial of a fractional dose of the HPV vaccine. The purpose of this research study is to determine if a fractional dose of the HPV vaccine produces a detectable immune response.
Participants will be assigned by chance (like flipping a coin) to either Gardasil (HPV-9) or Cervarix (HPV-2) FDA-approved vaccine. Participants will know which vaccine they are assigned to. Participants receive a fractional, one-fifth dose of the vaccine at the first visit. The study will last for one year and involve 4 visits. All visits will include blood draws.
To be eligible for the study you must:
- Be between the ages of 27-45
- Be in good health
- Have a flexible schedule to allow for vaccination on specific days determined by the clinic
Conditions which would prevent you from participating in this study:
- Have previously received the HPV vaccine
- Have any known impairment of the immune system
- Have HIV infection
- Pregnant or breast-feeding (women only)
Other Information:
- You will be compensated for time and travel during the study.
- Our clinic is located on the 11th floor of the Ninth and Jefferson Building at Harborview Medical Center and open Monday through Friday.