Fractional Dose of the HPV Vaccine

The University of Washington is seeking volunteers for an open-label, randomized trial of a fractional dose of the HPV vaccine. The purpose of this research study is to determine if a fractional dose of the HPV vaccine produces a detectable immune response.

Participants will be assigned by chance (like flipping a coin) to either Gardasil (HPV-9) or Cervarix (HPV-2) FDA-approved vaccine. Participants will know which vaccine they are assigned to. Participants receive a fractional, one-fifth dose of the vaccine at the first visit. The study will last for one year and involve 4 visits. All visits will include blood draws.

To be eligible for the study you must:

1. Be between the ages of 27-45
2. Be in good health
3. Have a flexible schedule to allow for vaccination on specific days determined by the clinic

Conditions which would prevent you from participating in this study:

1. Have previously received the HPV vaccine
2. Have any known impairment of the immune system
3. Have HIV infection
4. Pregnant or breast-feeding (women only)

Other Information:

• You will be compensated for time and travel during the study.
• Our clinic is located on the 11th floor of the Ninth and Jefferson Building at Harborview Medical Center and open Monday through Friday.