The University of Washington is seeking volunteers for a Phase 1/2 COVID-19 vaccine booster trial. The purpose of this clinical trial is to test the safety and effectiveness of a booster dose of the Novavax sub-unit protein vaccine in people who have received an EUA vaccine series.

The study will enroll:

• Participants who have completed an EUA vaccine series at least 12 weeks prior to joining the study.

• This includes individuals who have received either 2 doses of Pfizer OR 2 doses of Moderna OR 2 doses of Johnson & Johnson COVID-19 vaccines. You will not be eligible if you have received a 3rd (booster) COVID-19 vaccine.

The trial will last for about one year and will involve at least seven (7) in-person visits.

Participants will undergo a screening assessment to see whether they are eligible. Study visits will involve physical exams, blood draws, and vaccine injections. Participants will be asked to keep a diary of their vaccine reactions for seven (7) days after each injection.

To be eligible for the trial you must:

• Be 18 years of age or older

• Have received an EUA vaccine no less than twelve (12) weeks ago

Conditions which would prevent you from participating:

• Previous SARS-CoV-2 infection

• Have received a third (booster) COVID-19 vaccine

• Current pregnancy or breastfeeding

• Serious reactions to vaccines

• Immunocompromising conditions

Compensation:

For completing the entire study, participants will be compensated $800.

Clinic Location: Our clinic is located on the 11th floor of the Ninth and Jefferson Building at Harborview Medical Center. We are open Monday through Friday 8:30am to 5:30pm.