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Platelet Rich Plasma and Tendons

New Treatments for Tendinosis

What is tendinosis?

Tendinosis or tendinopathy is a degenerative condition of the tendon caused by repetitive microtrauma and a failed healing response. The tendon is the strong tissue that connects muscle to the bone. It is made of bundles of collagen fibrils. When a tendon is repetitively subjected to loads exceeding its capacity, some of the fibers begin to fail making the whole tendon weaker. The body tries to begin a healing response, but sometimes, because of continued stress, the age of a tendon, or other factors the tendon does not heal.

Tendinosis vs. Tendinitis

Tendinosis, sometimes called tendinopathy, is different than "tendonitis." Tendonitis is an acute inflammation of the tendon and occurs in response to a new activity or stress. Tendinitis will typically resolve with rest, ice, and anti-inflammatory medication. Tendinosis, on the other hand, is a long-standing degenerative process, and when tendinopathic tendons are biopsied there are no inflammatory cells present. Instead, the tendon is degenerative and the healing response has failed. Sometimes scar tissue or calcium deposits in the tendon are the result of the failed healing response.

What about anti-inflammatory medication?

Treatments targeting inflammation have limited effectiveness in the treatment of tendinosis since there is no inflammation present. Anti-inflammatory medications such as ibuprofen, naproxen, and similar prescription medications are good pain relievers which is why people with tendinosis may experience temporary relief when taking them. They will not, however, cure the problem of tendinosis. In fact, anti-inflammatory medication may actually impair tendon recovery as inflammation is the first stage of the healing process.

Newer treatments for tendinosis are all designed to stimulate healing. This can be done in a variety of ways.

Mechanotherapy

Certain types of exercises ("eccentric") or deep tissue massage may stimulate healing in tendons.

Nitroglycerin Patches

Nitroglycerin patches are usually used to lower blood pressure, however, studies have shown that they can have healing effects on tendons. The patch is cut into quarters and applied directly over the tendon. It typically takes 1-2 months to see improvement and works best when combined with eccentric exercises.

Needling of the tendon or tenotomy

Some studies have shown that repetitively poking or needling the tendon and causing it to bleed may induce healing. Blood is made up of several elements. An important element for the healing of tendons are the platelets. Platelets are packed with growth factors that can jump start the stalled healing process in tendinosis. In a tenotomy procedure, the area is numbed with local anesthetic and then the tendon is needled or repeatedly poked to create small fenestrations and cause the tendon to bleed. Tendons are relatively avascular and do not have a lot of blood vessels in them. Sometimes the needling procedure alone is enough to stimulate healing. Sometimes the needling or tenotomy is combined with other procedures.

Autologous Blood Injections

In autologous blood injections, a small amount of blood (2-3 cc) is taken from the patients arm and injected back into the degenerative portion of the tendon using ultrasound guidance after the tenotomy. The blood contains growth factors which can restart a stalled healing process.

In studies that have looked at autologous blood injections there is a reported 80% - 95% satisfaction rate, and about a 5% - 15% failure rate. In actual practice, around 60% of people improve significantly with two injections. The protocol we use is to do two injections four weeks apart.

Platelet Rich Plasma

Platelet rich plasma has received a significant amount of media attention and is becoming more popular. Initial studies are promising but there is still much to be learned.

In a PRP injection a small amount of patients blood is drawn from the patient, the blood is centrifuged and the platelets are harvested. PRP is then injected back into the degenerative area under ultrasound guidance. PRP has 3 – 9 times the growth factors that whole blood does and can stimulate healing. PRP has been used for over twenty years in dental and maxillofacial procedures. Its use in musculoskeletal injuries is relatively recent.

There are many basic science and animal studies that suggest that PRP is effective. There are also studies in humans suggesting PRP is effective. PRP is not a miracle cure. In chronic injuries it can restart the body's natural healing processes. Progress is usually slow. Typically, people will be about 20% better at 6 weeks and about 80% better at 12 weeks. A second injection is required in about 30% of people. A second injection (if needed) is usually not done until 12 weeks because significant improvement can occur up to that time period.

About 10% of people will not respond to PRP. Almost everybody improves. Not everybody gets back to 100%.

Frequently Asked Questions About PRP

1. What conditions are treated with PRP?

The indication which has been studied the most is for tendinosis or partial tears of most tendons:

Achilles
Rotator cuff
Tennis Elbow
Golfer's Elbow
Hamstring
Gluteus Medius
Plantar fasciosis

2. Can you treat arthritis with PRP?

There are a few studies which suggest PRP may be effective in osteoarthritis. It is more effective in mild to moderate arthritis and will likely not help severe, degenerative arthritis. Its use in arthritis is experimental and it is unlikely to be covered by insurance.

3. Do you treat chronic back or disk injuries with PRP?

PRP has not been studied in chronic back or disk injuries and these injections are not done at Hall Health.

4. Who does PRP at Hall Health?

Drs. Harmon, Drezner, and Rao all have extensive experience in the use of PRP and ultrasound.

5. What are the risks of PRP injection?

Since the PRP is prepared from your own body there is very little risk of infection. With any injection there is always a small risk of infection or bleeding. In addition, tendons which are degenerative may rupture with or without the injection of PRP. Some people will have pain during and after the procedure although this is typically fairly minimal. About 10% of people do not respond to PRP treatment. You may improve but get back to 100% of pre-injury level.

6. What should I during and after a PRP injection?

There is a small amount of discomfort when the blood is drawn to prepare the PRP. After the blood is drawn, the skin is cleaned and sterilized and then numbed using local anesthetic similar to the dentist's office. Pain during the procedure is usually minimal, although a minority of people will experience a deep cramping, aching discomfort which typically resolves after 10 – 15 minutes. After the procedure you will be asked to lay still with ice on the affected area for 15 minutes. The pain from the injury may be flared up for a few days to a week.

7. How long does it take?

The actual injection only takes a few minutes. However drawing and preparing the blood, and procedure set-up can take 15 – 30 minutes. After most injections you will be asked to remain still with ice on the area for 15 minutes. You're provider will tell you how long to schedule for your PRP appointment, typically 30 – 60 minutes depending on what you are having done.

8. What activity can I do after a PRP injection?

You should do only normal activities of daily living for the first two weeks – no additional exercise. Most people can go back to work right away. After two weeks you will begin a slow progression of activity. The exact progression depends on the injury site. For lower extremity injuries a typical progression would be stationary bike or swim at 2 weeks, elliptical trainer or stair stepper at 4 weeks. You will follow up with your provider at 6 weeks.

9. Is PRP covered by insurance?

You can ask your insurance company whether or not it is covered.  You will need to provide them with the billing code 0232T and our tax ID # 91-1220843.  Most insurers consider it experimental although there is good evidence that it is effective for tendon conditions.  You may also check with our billing department, 206-616-1881 to see if your insurance has covered PRP for other patients. 

10. What is the cost of PRP?

PRP is $800 per injection when ultrasound is used. It is $500 per injection on some joint injections where US is not required.

11. Is there a role for cortisone injections?

Cortisone is a potent anti-inflammatory so for acute tendinitis it can be useful. It is also catabolic, meaning it dissolves scar tissue. In tendons where there is a lot of scar tissue, even if there is not inflammation, there may be a role. There is also a role for cortisone in adhesive capsulitis or frozen shoulder. Your doctor can discuss which options are best for your situation.

12. How do I get a PRP injection?

You should schedule an office visit with one of our providers. You should bring in previous MRIs or x-rays on a CD. You will need to be seen prior to getting your PRP injection to make sure it is the right thing for you. If you are a good candidate for PRP therapy you can schedule for the injection after that.

13. Do you see problems not requiring PRP?

Yes! We are a full service sports medicine clinic!

PRP in The News

Dr. Harmon performing PRP in patient with tennis elbow (with King 5 video)

Seattle Times article featuring Hall Health

Seeking Help for an Injury: At Any Price (NY Times)

A Promising Treatment for Athletes, in blood (NY Times)

Role of Ultrasound

At Hall Health, musculoskeletal ultrasound is used to diagnose tendinopathy, target treatment and follow the progress of tendons. Physicians at Hall Health have been on the forefront of this emerging technology. Ultrasound is used to visualize the tendinopathic region of the tendon in order to more accurately focus treatment.

Some injections, like cortisone, do not have to be placed at the exact site on injury because the medication diffuses. With a biologic treatment, like PRP, it is important to get the substance at the exact site of injury or degeneration.

Ultrasound can also be used to diagnose problems and follow the progress of a healing tendon.

Appointment Scheduling

  • You do not need a referral, however, if your doctor is referring you a formal referral or prescription as well as any clinic notes are appreciated.
  • Bring any copies of recent x-rays or MRIs. A CD is preferred.
  • Call Hall Health Sports Medicine Clinic at 685-1044 and speak to the sports medicine patient service representative. They will schedule you for the appropriate time slot. If no one answers, please leave a message and you will be called back generally within 24 hours.
  • Typically the first appointment will be a consultation with a physician to confirm or make a diagnosis and discuss if you are a good candidate for this type of procedure. An ultrasound may be performed to assess the tendon .
  • Directions to Hall Health can be found here.
  • Please arrive 15 minutes prior to your scheduled appointment.

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