The one study reviewed here examines a change
in the form of a drug (shape and character) and its effectiveness in reducing poisonings.
Review of other interventions:
Study design and target population
|Before and after design.
Children admitted to Madigan General Hospital
for poisoning from ferrous sulfate, 1964 to 1968.
|Replacement of drug from small tablet to large capsule.
|No admissions for ferrous sulfate poisonings after
change in drug form. Expected number from previous years is 20-25.
Study quality and conclusions
|No controls used in study.
Effect of intervention may be confounded by
Summary of miscellaneous interventions
The study reviewed above showed that making
pills unchewable and too large for small children to swallow possibly played a role
in reducing poisonings from that drug. However, there were no control groups in
the study, and the before and after design cannot adjust for secular trends in the
Recommendations on miscellaneous programs
At this time, no recommendation can be made
on this intervention. In fact, making a pill that is too large for children to swallow
may serve to increase the risk of choking on the pill (as will its unchewable nature).