Effects of Leukoreduction on Infectious Risk in Trauma
Key Investigator: Avery Nathens, M.D. Ph.D., M.P.H.
University of Washington Department of Surgery
Funding Source: National Institute of Health
Many severely injured patients survive their initial resuscitation only to experience subsequent nosocomial infection and multiple organ failure, two of the most frequent causes of excess morbidity in this population. Several lines of clinical and experimental evidence implicate allogeneic blood transfusion, a critical component of resuscitation, in the development of these sequelae. This study will evaluate whether transfusion of leukoreduced blood products will reduce the incidence of infection and multiple organ failure in critically injured patients.