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Case 2: Nevirapine-Induced Hepatotoxicity

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A The patient likely has nevirapine-induced hepatotoxicity. Antiretroviral therapy should be temporarily discontinued until symptoms resolve and hepatic aminotransferase levels return to baseline. Nevirapine should not be used again for this patient.

This answer is correct. The constitutional symptoms, laboratory abnormalities, and timing of the reaction indicate a probable nevirapine-induced hepatotoxicity. Patients often have systemic symptoms associated with nevirapine-induced hepatotoxicity. The proper course of management is to promptly discontinue nevirapine, and the patient should not receive nevirapine again. Treatment with corticosteroids is not recommended.


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