Figure 3. Relationship of UGT1A1 Allelic Variants on Total Bilirubin Levels
Abbreviations: PI = protease inhbitor; LPV = lopinavir; NFV = nelfinavir; RTV = ritonavir; ATV = atazanavir; IDV = indinavir
This graph shows the proportion of patients who had jaundice (defined as a total bilirubin level greater than 2.5 mg/dl [43 umol/L] on at least 2 occasions), by presence and type of protease inhibitor (PI) and UGT1A1 allelic variant. This study involved 96 participants and 1386 measurements of total bilirubin levels during a median follow-up of 6 years.
From: Rotger M, Taffe P, Bleiber G, et al. Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia. J Infect Dis. 2005;192:1381-6.
From: HIV Web Study <www.hivwebstudy.org>