Figure 10. Phenotypic Drug Susceptibility Curve Showing Patient's HIV Resistant to Drug
This graph shows a phenotypic susceptibility curve comparing the effect of a single antiretroviral drug on the patient's HIV and a laboratory reference (wild-type strain). The wild-type strain is known to be susceptible to the drug tested. The graph shows a significant shift to the right for the patient's HIV isolate compared with the wild-type strain, thus a higher concentration of drug is required to inhibit replication of the patient's HIV. Conceptually, this graph is showing the patient's HIV strain is resistant to the medication tested. In the actual phenotypic assay, the exact level of resistance is calculated by dividing the IC50 of the patient's isolate by the IC50 of the wild-type laboratory strain.
From: HIV Web Study <www.hivwebstudy.org>