Case 3: Resistance to Non-Nucleoside Reverse Transcriptase Inhibitors

You answered:

	Although the K103N mutation reflects resistance to efavirenz, the patient should have an excellent virologic response to nevirapine.

This answer is incorrect. The K103N mutation causes high-level resistance to efavirenz as well as cross-resistance to nevirapine and delavirdine.

Choose another answer:

	The patient is not likely to have a significant virologic response to efavirenz or nevirapine.
	Although the K103N mutation reflects resistance to efavirenz, the patient should have an excellent virologic response to delavirdine.
	If the patient is placed back on efavirenz and the K103N mutation remerges, efavirenz should be continued because the presence of the K103N mutation will markedly reduce viral fitness.