Figure 1. NNRTI Mechanism of Action and Mechanism of Resistance

With drug-sensitive virus, drugs in the NNRTI class bind to the hydrophobic pocket near the active site of reverse transcriptase and block DNA polymerization. With NNRTI-resistant virus, the NNRTI binding is blocked and DNA polymerization can proceed normally. This figure is from Clavel F, Hance AJ. HIV drug resistance. N Engl J Med. 2004;350:1023-35. The figure was reproduced with permission from the Massachusetts Medical Society. Copyright © 2004 Massachusetts Medical Society. All rights reserved.

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