Figure 2. Analysis of HIV Phenotypic Patterns in Patients Failing a Protease Inhibitor-Based Regimen

This study involved patients who experienced virologic failure (HIV RNA greater than 400 copies/ml) while taking a protease inhibitor-based regimen for at least 3 months. Susceptibility results are shown for multiple protease inhibitors, based on prior virologic failure with indinavir or nelfinavir. Reduced phenotypic susceptibility is defined as a greater than 4-fold increase in the 50% inhibitory concentration compared with drug-sensitive virus. This figure is based on data from Kemper CA, Witt MD, Keiser PH, et al. Sequencing of protease inhibitor therapy: insights from an analysis of HIV phenotypic resistance in patients failing protease inhibitors. AIDS. 2001;15:609-15.

[Close Window]