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Case 2: Antiretroviral Regimens

Author: David H. Spach, MD

Case last updated: December 16, 2008

A 36-year-old woman has recently been diagnosed with HIV infection. Her initial laboratory studies show a CD4 count of 100 cells/mm3 and HIV RNA of 87,500 copies/ml. Repeat laboratory studies performed one month later show similar results. She has not had any HIV-related complications history. Her physical examination is normal. She is very interested in starting antiretroviral therapy. Her only medication that she takes is trimethoprim-sulfamethoxazole (Bactrim, Septra).

According to the November 2008 DHHS Guidelines for the Use of Antiretroviral Agents, which of the following statements is TRUE regarding initial antiretroviral therapy?

A Zidovudine-lamivudine (Combivir) plus efavirenz (Sustiva) is considered a preferred regimen.
B Tenofovir-emtricitabine (Truvada) plus ritonavir (Norvir) plus darunavir (Prezista) is considered a preferred regimen.
C Abacavir (Ziagen) plus tenofovir (Viread) plus lamivudine (Epivir) is considered an alternative regimen.
D Stavudine (Zerit) plus lamivudine (Epivir) plus lopinavir-ritonavir (Kaletra) is considered a preferred regimen.