Figure 3. Drug Resistance Rates in Patients Recently Infected with HIV in 10 North American Cities
Abbreviations: NRTI = Nucleoside Reverse Transcriptase Inhibitor; NNRTI = Non-Nucleoside Reverse Transcriptase Inhibitor; PI = Protease Inhibitor; Multi = Multi-Drug-Resistant Isolates
This graph shows the frequency of antiretroviral drug resistance among individuals with acute or recent HIV infection who have not received antiretroviral therapy prior to drug resistance testing. The patients participated in the study were seen in one of 10 major North American cities. As shown, the frequency of antiretroviral drug resistance represents high-level phenotypic resistance defined by a value of at least 10 times the ratio of the 50 percent inhibitory concentration (IC50) when comparing the patient’s HIV isolate with a known drug-sensitive reference strain. Resistance rates increased from 1995-1998 to 1999-2000 in all drug classes, as well as in multi-drug resistant isolates. Data from Little SJ, Holte S, Routy JP, et al. Antiretroviral-drug resistance among patients recently infected with HIV. N Engl J Med. 2002;347:385-94.
From: HIV Web Study <www.hivwebstudy.org>