Figure 4. Kaplan-Meier Estimates of the Time to Viral Suppression after Initiating Antiretroviral Therapy Related to Base-Line Phenotypic Resistance Data Obtained During Acute or Early HIV Infection

Figure 4. Kaplan-Meier Estimates of the Time to Viral Suppression after
Initiating Antiretroviral Therapy Related to Base-Line Phenotypic Resistance
Data Obtained During Acute or Early HIV Infection

The IC50 result was obtained from phenotypic resistance test and represents the concentration of the antiretroviral drug required to cause 50% inhibition of HIV replication; these results are compared with the IC50 of a drug-sensitive reference strain to determine the IC50 ratio. The graph line with IC50 ratio less than 2.5 represents patients with drug-susceptible HIV, whereas the graph line with IC50 ratio greater than 10 represents those patients who had HIV with resistance to at least one antiretroviral drug. The time from initiation of antiretroviral therapy to suppression of HIV RNA to less than 500 copies/ml was significantly less in those subjects who had drug-susceptible HIV at baseline. Results from the resistance testing were not known when the patients received antiretroviral therapy. Figure reproduced from Little SJ, Holte S, Routy JP, et al. Antiretroviral-drug resistance among patients recently infected with HIV. N Engl J Med. 2002;347:385-94. Reproduced with permission from the Massachusetts Medical Society. Copyright © 2002 Massachusetts Medical Society. All rights reserved.

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