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Case 2: References

  1. Balfour HH Jr. Antiviral Drugs. N Engl J Med. 1999;340:1255-68.
    [The following link will open in a new window. PubMed Abstract]
  2. Gilbert C, Bestman-Smith J, Boivin G. Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms. Drug Resist Updat. 2002;5:88-114.
    [The following link will open in a new window. PubMed Abstract]
  3. Levin MJ, Bacon TH, Leary JJ. Resistance of herpes simplex virus infections to nucleoside analogues in HIV-infected patients. Clin Infect Dis. 2004;39 Suppl 5:S248-57.
    [The following link will open in a new window. PubMed Abstract]
  4. Pottage JC Jr, Kessler HA. Herpes simplex virus resistance to acyclovir: clinical relevance. Infect Agents Dis. 1995;4:115-24.
    [The following link will open in a new window. PubMed Abstract]
  5. Crumpacker CS, Schnipper LE, Marlowe SI, Kowalsky PN, Hershey BJ, Levin MJ. Resistance to antiviral drugs of herpes simplex virus isolated from a patient treated with acyclovir.  N Engl J Med. 1982;306:343-6.
    [The following link will open in a new window. PubMed Abstract]
  6. Reyes M, Shaik NS, Graber JM, et al. Acyclovir-resistant genital herpes among persons attending sexually transmitted disease and human immunodeficiency virus clinics. Arch Intern Med. 2003;163:76-80.
    [The following link will open in a new window. PubMed Abstract]
  7. Erlich KS, Mills J, Chatis P, et al. Acyclovir-resistant herpes simplex virus infections in patients with the acquired immunodeficiency syndrome. N Engl J Med. 1989;320:293-6.
    [The following link will open in a new window. PubMed Abstract]
  8. Gateley A, Gander RM, Johnson PC, Kit S, Otsuka H, Kohl S. Herpes simplex virus type 2 meningoencephalitis resistant to acyclovir in a patient with AIDS. J Infect Dis. 1990;16:711-5.
    [The following link will open in a new window. PubMed Abstract]
  9. Field HJ. Herpes simplex virus antiviral drug resistance--current trends and future prospects. J Clin Virol. 2001;21:261-9
    [The following link will open in a new window. PubMed Abstract]
  10. Marks GL, Nolan PE, Erlich KS, Ellis MN. Mucocutaneous dissemination of acyclovir-resistant herpes simplex virus in a patient with AIDS. Rev Infect Dis. 1989;11:474-6.
    [The following link will open in a new window. PubMed Abstract]
  11. Safrin S, Assaykeen T, Follansbee S, Mills J. Foscarnet therapy for acyclovir-resistant mucocutaneous herpes simplex virus infection in 26 AIDS patients: preliminary data. J Infect Dis. 1990;161:1078-84.
    [The following link will open in a new window. PubMed Abstract]
  12. Safrin S, Crumpacker C, Chatis P, et al. A controlled trial comparing foscarnet with vidarabine for acyclovir-resistant mucocutaneous herpes simplex in the acquired immunodeficiency syndrome. The AIDS Clinical Trials Group. N Engl J Med. 1991;325:551-5.
    [The following link will open in a new window. PubMed Abstract]
  13. Erlich KS, Jacobson MA, Koehler JE, et al. Foscarnet therapy for severe acyclovir-resistant herpes simplex virus type-2 infections in patients with the acquired immunodeficiency syndrome (AIDS). An uncontrolled trial. Ann Intern Med. 1989;110:710-3.
    [The following link will open in a new window. PubMed Abstract]
  14. Guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations of the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the HIV Medicine Association/Infectious Diseases Society of America (HIVMA/IDSA). June 18, 2008. Available at:
    [The following link will open in a new window. AIDSinfo - Accessed September 10, 2008]
  15. Snoeck R, Andrei G, De Clercq E, Gerard M, Clumeck N, Tricot G., Sadzot-Delvaux C. A new topical treatment for resistant herpes simplex infections. N Engl J Med. 1993;329:968-9.
    [The following link will open in a new window. PubMed Abstract]
  16. Lalezari J, Schacker T, Feinberg J, et al. A randomized, double-blind, placebo-controlled trial of cidofovir gel for the treatment of acyclovir-unresponsive mucocutaneous herpes simplex virus infection in patients with AIDS. J Infect Dis. 1997;176:892-8.
    [The following link will open in a new window. PubMed Abstract]
  17. Lalezari JP, Drew WL, Glutzer E, et al. Treatment with intravenous (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]-cytosine of acyclovir-resistant mucocutaneous infection with herpes simplex virus in a patient with AIDS. J Infect Dis. 1994;170:570-2.
    [The following link will open in a new window. PubMed Abstract]
  18. Kessler HA, Hurwitz S, Farthing C, et al. Pilot study of topical trifluridine for the treatment of acyclovir-resistant mucocutaneous herpes simplex disease in patients with AIDS (ACTG 172). AIDS Clinical Trials Group. J Acquir Immune Defic Syndr Hum Retrovirol. 1996;12:147-52.
    [The following link will open in a new window. PubMed Abstract]
  19. Gilbert J, Drehs MM, Weinberg JM. Topical imiquimod for acyclovir-unresponsive herpes simplex virus 2 infection. Arch Dermatol. 2001;137:1015-7.
    [The following link will open in a new window. PubMed Abstract]
  20. Martinez V, Molina JM, Scieux C, Ribaud P, Morfin F. Topical imiquimod for recurrent acyclovir-resistant HSV infection. Am J Med. 2006;119:e9-11.
    [The following link will open in a new window. PubMed Abstract]

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